Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/114691

Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez Cabrero, David; Synergy-COPD consortium
Universitat de Barcelona
Background and hypothesis: Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and management. Implicit with the classical "spill over" hypothesis is that COPD heterogeneity is driven by the pulmonary events of the disease. Alternatively, we hypothesized that COPD heterogeneities result from the interplay of mechanisms governing three conceptually different phenomena: 1) pulmonary disease, 2) systemic effects of COPD and 3) co-morbidity clustering, each of them with their own dynamics. Objective and method: To explore the potential of a systems analysis of COPD heterogeneity focused on skeletal muscle dysfunction and on co-morbidity clustering aiming at generating predictive modeling with impact on patient management. To this end, strategies combining deterministic modeling and network medicine analyses of the Biobridge dataset were used to investigate the mechanisms of skeletal muscle dysfunction. An independent data driven analysis of co-morbidity clustering examining associated genes and pathways was performed using a large dataset (ICD9-CM data from Medicare, 13 million people). Finally, a targeted network analysis using the outcomes of the two approaches (skeletal muscle dysfunction and co-morbidity clustering) explored shared pathways between these phenomena. Results: (1) Evidence of abnormal regulation of skeletal muscle bioenergetics and skeletal muscle remodeling showing a significant association with nitroso-redox disequilibrium was observed in COPD; (2) COPD patients presented higher risk for co-morbidity clustering than non-COPD patients increasing with ageing; and, (3) the on-going targeted network analyses suggests shared pathways between skeletal muscle dysfunction and co-morbidity clustering. Conclusions: The results indicate the high potential of a systems approach to address COPD heterogeneity. Significant knowledge gaps were identified that are relevant to shape strategies aiming at fostering 4P Medicine for patients with COPD.
Malalties pulmonars obstructives cròniques
Comorbiditat
Citoquines
Investigació mèdica
Estrès oxidatiu
Chronic obstructive pulmonary diseases
Comorbidity
Cytokines
Medicine research
Oxidative stress
cc-by (c) Roca Torrent, Josep et al., 2014
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
BioMed Central
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez Cabrero, David; Synergy-COPD consortium
Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez Cabrero, David; Synergy-COPD consortium
Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez-Cabrero, David; Synergy-COPD consortium
Gomez Cabrero, David; Menche, Jörg; Cano, Isaac; Abugessaisa, Imad; Huertas Migueláñez , M.Mercedes , M.; Tenyi, Akos; Marin-de Mas, Igor; Kiani, Narsis A.; Marabita, Francesco; Falciani, Francesco; Burrowes, Kelly; Maier, Dieter; Wagner, P. D. (Peter D.); Selivanov, Vitaly A.; Cascante i Serratosa, Marta; Roca Torrent, Josep; Barabási, Albert László; Tegnér, Jesper
Gomez Cabrero, David; Menche, Jörg; Cano, Isaac; Abugessaisa, Imad; Huertas Migueláñez , M.Mercedes , M.; Tenyi, Akos; Marin-de Mas, Igor; Kiani, Narsis A.; Marabita, Francesco; Falciani, Francesco; Burrowes, Kelly; Maier, Dieter; Wagner, P. D. (Peter D.); Selivanov, Vitaly A.; Cascante i Serratosa, Marta; Roca Torrent, Josep; Barabási, Albert László; Tegnér, Jesper
 

Coordinación

 

Patrocinio