An efficient and reproducible method to culture Bergmann and cortical radial glia using textured PMMA

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Title:	An efficient and reproducible method to culture Bergmann and cortical radial glia using textured PMMA
Author:	Álvarez Pinto, Zaída; Sena, Elena; Mattotti, Marta; Engel López, Elisabeth; Alcantara, Soledad
Other authors:	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Institut de Bioenginyeria de Catalunya; Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
Abstract:	Radial glia cells comprise the principal population of neural stem cells (NSC) during development. Attempts to develop reproducible radial glia and NSC culture methods have met with variable results, yielding non-adherent cultures or requiring the addition of growth factors. Recent studies demonstrated that a 2-µm patterned poly-methyl methacrylate (ln2 PMMA) grooved scaffold, by mimicking the biophysical and microtopographic properties of the embryonic NSC niche, induces the de-differentiation of glial cells into functional radial glia cell
Abstract:	Peer Reviewed
Subject(s):	-Àrees temàtiques de la UPC::Enginyeria dels materials -Biomedical materials -Astrocytes -Radial glia -Bergmann glia -Progenitors -Poly-methyl methacrylate (PMMA) -Micro-patterning -Surface topography -Materials biomèdics
Rights:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Document type:	Article - Published version Article
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