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Differential neuronal and glial behavior on flat and micro patterned chitosan films
Mattotti, Marta; Álvarez Pinto, Zaída; Delgado Muñoz, Luis; Mateos Timoneda, Miguel Ángel; Aparicio, Conrado; Planell Estany, Josep Anton; Alcántara Horrillo, Soledad; Engel López, Elisabeth
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. ICARUS - Intelligent Communications and Avionics for Robust Unmanned Aerial Systems; Universitat Politècnica de Catalunya. BIBITE - Biomaterials, Biomecànica i Enginyeria de Teixits
Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan either flat or patterned with grooves in the micrometric range. Chitosan demonstrated to be a good substrate for the attachment and growth of both neurons and glial cells. Chitosan micropatterns promoted glial cell maturation, suggesting astroglial activation. Nevertheless, those mature/reactive glial cells were permissive for axonal growth. Axons aligned and organized along the patterned grooves and the size of the linear topographic patterns is also affecting neurite and cell response. Patterns with 10 µm width induced fasciculation of axons, which can be useful for CNS tissue engineering substrates when precise orientation of the axonal outgrowth is desired.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria dels materials
Chitosan
Brain
Brain
Chitosan
Glia
Micropattern
Neuron
Quitosan
info:eu-repo/semantics/submittedVersion
Article
         

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