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Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD.
Sala Vila, Aleix; Harris, William S.; Cofán Pujol, Montserrat; Pérez-Heras, Ana Maria; Pintó Sala, Xavier; Lamuela Raventós, Rosa Ma.; Covas Planells, María Isabel; Estruch Riba, Ramon; Ros Rahola, Emilio
Universitat de Barcelona
The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA þ DHA was 0·9 g/d and the mean omega-3 index was 7·1%. In multivariate models, EPA þ DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P,0·001). No associations with other dietary fatty acids were observed. Although the single most influential determinant of the omega-3 index measured here was the intake of EPA þ DHA, it explained little of the former"s variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
2013-10-03
Dieta
Malalties cardiovasculars
Factors de risc en les malalties
Àcids grassos omega-3
Diet
Cardiovascular diseases
Risk factors in diseases
Omega-3 fatty acids
(c) Cambridge University Press, 2011
Article
info:eu-repo/semantics/publishedVersion
Cambridge University Press
         

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Sala Vila, Aleix; Harris, William S.; Cofán Pujol, Montserrat; Pérez-Heras, Ana Maria; Pintó Sala, Xavier; Lamuela Raventós, Rosa Ma.; Covas Planells, María Isabel; Estruch Riba, Ramon; Ros Rahola, Emilio
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Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
Medina Remón, Alexander; Vallverdú i Queralt, Anna; Arranz Martínez, Sara; Ros Rahola, Emilio; Martínez-González, Miguel Ángel, 1957-; Sacanella Meseguer, Emilio; Covas Planells, María Isabel; Corella Piquer, Dolores; Salas Salvadó, Jordi; Gómez Gracia, Enrique; Ruiz-Gutiérrez, V.; Lapetra, J.; García Valdueza, Marta; Arós, Fernando; Saez Tormo, Guillermo; Serra Majem, Lluís; Pintó Sala, Xavier; Vinyoles, Ernest; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma.
 

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