Title:
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Tying malaria and microRNAs: from the biology to future
diagnostic perspectives
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Author:
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Rubio, Mercedes; Bassat Orellana, Quique; Estivill, Xavier, 1955-; Mayor Aparicio, Alfredo Gabriel
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Abstract:
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Symptoms caused by bacterial, viral and malarial infections
usually overlap and aetiologic diagnosis is difficult. Patient
management in low-resource countries with limited laboratory
services has been based predominantly on clinical evaluation and
syndromic approaches. However, such clinical assessment has
limited accuracy both for identifying the likely aetiological
cause and for the early recognition of patients who will
progress to serious or fatal disease. Plasma-detectable
biomarkers that rapidly and accurately diagnose severe
infectious diseases could reduce morbidity and decrease the
unnecessary use of usually scarce therapeutic drugs. The
discovery of microRNAs (miRNAs) has opened exciting new avenues
to identify blood biomarkers of organ-specific injury. This
review assesses current knowledge on the relationship between
malaria disease and miRNAs, and evaluates how future research
might lead to the use of these small molecules for identifying
patients with severe malaria disease and facilitate treatment
decisions. |
Subject(s):
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-Malària -Micro RNAs -Malaria -MicroRNAs |
Rights:
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cc by (c) Rubio et al., 2016
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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BioMed Central
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