dc.contributor.author
Hernández Romero, Delia
dc.contributor.author
Altuna, Marta
dc.contributor.author
Cuevas, Carmen
dc.contributor.author
Aligué i Alemany, Rosa Maria
dc.contributor.author
Albericio Palomera, Fernando
dc.contributor.author
Álvarez Domingo, Mercedes
dc.date.issued
2014-07-18T11:58:36Z
dc.date.issued
2014-07-18T11:58:36Z
dc.date.issued
2008-09-03
dc.date.issued
2014-07-18T11:58:37Z
dc.identifier
https://hdl.handle.net/2445/56045
dc.description.abstract
Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.
dc.format
application/pdf
dc.publisher
American Chemical Society
dc.relation
Versió postprint del document publicat a: http://dx.doi.org/10.1021/jm800513w
dc.relation
Journal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730
dc.relation
http://dx.doi.org/10.1021/jm800513w
dc.rights
(c) American Chemical Society , 2008
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Compostos heterocíclics
dc.subject
Medicaments antineoplàstics
dc.subject
Síntesi de pèptids
dc.subject
Espectroscòpia de ressonància magnètica nuclear
dc.subject
Heterocyclic compounds
dc.subject
Antineoplastic agents
dc.subject
Peptide synthesis
dc.subject
Nuclear magnetic resonance spectroscopy
dc.title
Synthesis and antitumor activity of mechercharmycin A analogues
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
