dc.contributor.author
Isidro Llobet, Albert
dc.contributor.author
Just Baringo, Xavier
dc.contributor.author
Ewenson, Ariel
dc.contributor.author
Álvarez Domingo, Mercedes
dc.contributor.author
Albericio Palomera, Fernando
dc.date.issued
2013-12-20T12:30:39Z
dc.date.issued
2013-12-20T12:30:39Z
dc.date.issued
2013-12-20T12:30:40Z
dc.identifier
https://hdl.handle.net/2445/48634
dc.description.abstract
A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.
dc.format
application/pdf
dc.relation
Biopolymers, 2007, vol. 88, num. 5, p. 733-737
dc.rights
(c) Wiley, 2007
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Reaccions químiques
dc.subject
Síntesi de pèptids
dc.subject
Chemical reactions
dc.subject
Peptide synthesis
dc.title
Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/submittedVersion
