Transient platelet hyporesponsiveness in non-ischemic arrhythmogenic cardiac arrest after achieving restoration of spontaneous circulation in pigs.

Abstract

This study shows that variable and often attenuated platelet reactivity after CA, together with neutral OHCA outcome data argues against indiscriminate antiplatelet loading before the cause of shock is clarified. For ambiguous prehospital cardiogenic shock, initial management should prioritize early coronary angiography and comprehensive shock care, reserving full antiplatelet loading for those in whom AMI is confirmed or strongly suspected per local protocols.