A gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine B

dc.contributor.author
Bradshaw, Ben
dc.contributor.author
Luque Corredera, Carlos
dc.contributor.author
Bonjoch i Sesé, Josep
dc.date.accessioned
2026-01-10T22:51:32Z
dc.date.available
2026-01-10T22:51:32Z
dc.date.issued
2026-01-09T09:56:49Z
dc.date.issued
2026-01-09T09:56:49Z
dc.date.issued
2014-04-03
dc.date.issued
2026-01-09T09:56:50Z
dc.identifier
1359-7345
dc.identifier
https://hdl.handle.net/2445/225192
dc.identifier
630295
dc.identifier.uri
http://hdl.handle.net/2445/225192
dc.description.abstract
The synthesis of the Lycopodium alkaloid ( )-cermizine B (1), which establishes its absolute configuration, is achieved by combining asymmetric organocatalysis and an uninterrupted eight-step reaction sequence, followed by a final reduction step. This ''pot-economy'' strategy provides access to the cis-phlegmarine stereo parent embedded in 1 for the first time, rapidly and on a gram-scale.
dc.format
5 p.
dc.format
application/pdf
dc.language
eng
dc.publisher
Royal Society of Chemistry
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1039/c4cc01708k
dc.relation
Chemical Communications, 2014, vol. 50, p. 7099-7102
dc.relation
https://doi.org/10.1039/c4cc01708k
dc.rights
(c) Bradshaw, B. et al., 2014
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Medicaments
dc.subject
Alcaloides
dc.subject
Síntesi orgànica
dc.subject
Drugs
dc.subject
Alkaloids
dc.subject
Organic synthesis
dc.title
A gram-scale route to phlegmarine alkaloids: rapid total synthesis of (-)-cermizine B
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion


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