Analysing polypeptide antibiotics residues in animal muscle tissues: The crucial role of HRMS

Abstract

High resolution mass spectrometry (HRMS) has undergone an exciting phase of technological evolution. Time of flight instruments with significantly higher resolution and larger dynamic range have become available. Furthermore, a new type of mass spectrometer, the Orbitrap gave a significant impetus to high resolution mass spectrometry. These instruments are directly challenging the more traditional tandem mass spectrometers (QqQ). Recent studies show that sufficiently high resolving HRMS instrumentation is not only suited for screening but can be used for reliable quantitative purposes. HRMS should be able to dislodge QqQ in most analytical fields when some currently still existing HRMS hard and even more relevant software related limitations will be solved.