dc.contributor.author
Xifra, Raúl
dc.contributor.author
Lukach, Andrés E.
dc.contributor.author
Turcu, Andreea L.
dc.date.issued
2025-04-30T10:23:58Z
dc.date.issued
2025-04-30T10:23:58Z
dc.date.issued
2024-07-25
dc.date.issued
2025-04-30T10:23:58Z
dc.identifier
https://hdl.handle.net/2445/220718
dc.description.abstract
<span style="color:rgb( 34 , 34 , 34 )">Solifenacin (SFC) is a potent muscarinic antagonist that effectively reduces bladder muscle contraction, thereby alleviating symptoms such as frequency of micturition and urgency. Oxidation of SFC leads to the formation of impurities like Impurity K. Effective analysis and control of this impurity is crucial for ensuring compliance with regulatory standards and safeguarding patient health. To address these challenges, we propose a novel one-step synthesis of Impurity K from SFC. Impurity K was synthesized using cerium(IV) ammonium nitrate (CAN) in water/acetonitrile as the solvent. Additionally, we describe a new HPLC-MS method for the detection of Impurity K in solifenacin succinate tablets.</span>
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/doi:10.3390/molecules29133011
dc.relation
Molecules, 2024, vol. 29, num.13, p. 3011
dc.relation
https://doi.org/doi:10.3390/molecules29133011
dc.rights
cc-by (c) Raúl Xifra, et al., 2024
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Receptors colinèrgics
dc.subject
Acetylcholine receptors
dc.title
Facile Access to Solifenacin Impurity K: One-Step Synthesis and an HPLC-MS Method for Its Determination.
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
