Proximity-induced pharmacology for amyloid-related diseases<br />

dc.contributor.author
Bertran-Mostazo, Andrea
dc.contributor.author
Putriute, Gabrielé
dc.contributor.author
Álvarez-Berbel, Irene
dc.contributor.author
Busquets i Viñas, Ma. Antonia
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Galdeano Cantador, Carlos
dc.contributor.author
Espargaró Colomé, Alba
dc.contributor.author
Sabaté Lagunas, Raimon
dc.date.issued
2024-10-21T10:49:16Z
dc.date.issued
2024-10-21T10:49:16Z
dc.date.issued
2024-03-04
dc.date.issued
2024-10-21T10:49:16Z
dc.identifier
2073-4409
dc.identifier
https://hdl.handle.net/2445/215920
dc.identifier
746915
dc.description.abstract
<p>Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge</p><p>approach to treating conditions such as Alzheimer’s disease and other forms of dementia. By bringing</p><p>small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects</p><p>that can break down pathogenic proteins and reduce the buildup of plaques. One of the most</p><p>promising aspects of this drug discovery modality is that it can be used to target specific types of</p><p>amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer’s</p><p>disease. This level of specificity could allow for more targeted and effective treatments. With ongoing</p><p>research and development, it is hoped that these treatments can be refined and optimized to provide</p><p>even greater benefits to patients. As our understanding of the underlying mechanisms of these</p><p>diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly</p><p>important tool in the fight against dementia and other related conditions.</p>
dc.format
1 p.
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application/pdf
dc.format
application/pdf
dc.language
eng
dc.publisher
MDPI
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/cells13050449
dc.relation
Cells, 2024, vol. 13
dc.relation
https://doi.org/10.3390/cells13050449
dc.rights
cc-by (c) Bertran-Mostazo, A. et al., 2024
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject
Malalties neurodegeneratives
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Amiloïdosi
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Disseny de medicaments
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Neurodegenerative Diseases
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Amyloidosis
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Drug design
dc.title
Proximity-induced pharmacology for amyloid-related diseases<br />
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion


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