dc.contributor.author
Soriano-Meseguer, Sara
dc.contributor.author
Fuguet i Jordà, Elisabet
dc.contributor.author
Port, Adriana
dc.contributor.author
Rosés Pascual, Martí
dc.date.issued
2024-03-05T18:46:15Z
dc.date.issued
2024-03-05T18:46:15Z
dc.date.issued
2023-06-30
dc.date.issued
2024-03-05T18:46:15Z
dc.identifier
https://hdl.handle.net/2445/208414
dc.description.abstract
Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones already established for other PAMPA membranes using statistical tools. The results indicate that both skin membranes are similar to each other in their physicochemical properties. However, they are different from other PAMPA membranes (e.g., intestinal absorption and blood– brain PAMPAs), mainly in terms of hydrophobicity and hydrogen bonding properties. Next, all PAMPA membranes have been compared to relevant biological processes also characterized through the solvation parameter model. The results highlight that skin-PAMPA membranes are a very good choice to emulate skin permeability.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/https://doi.org/10.3390/membranes13070640
dc.relation
Membranes, 2023, vol. 13, p. 1-12
dc.relation
https://doi.org/https://doi.org/10.3390/membranes13070640
dc.rights
cc-by (c) Soriano-Meseguer, S. et al., 2023
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject
Absorció intestinal
dc.subject
Intestinal absorption
dc.title
Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
