dc.contributor.author
Trejo, Angela
dc.contributor.author
Masdeu, Carme
dc.contributor.author
Serrano-Pérez, Irene
dc.contributor.author
Pedrola, Marina
dc.contributor.author
Juanola, Narcís
dc.contributor.author
Ghashgaei, Ouldouz
dc.contributor.author
Jiménez Galisteo, Mª Guadalupe
dc.contributor.author
Lavilla Grífols, Rodolfo
dc.contributor.author
Palacios, Francisco
dc.contributor.author
Alonso, Concepción
dc.contributor.author
Viñas, Miquel
dc.date.issued
2023-02-24T18:41:57Z
dc.date.issued
2023-02-24T18:41:57Z
dc.date.issued
2023-01-03
dc.date.issued
2023-02-24T18:41:57Z
dc.identifier
https://hdl.handle.net/2445/194162
dc.description.abstract
New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiological guidance for medicinal chemistry is a powerful tool to design new and effective antimicrobials. In this case, the readily synthesized compounds open new possibilities in the search for antimicrobials active on mycolic acid-containing bacteria.
dc.format
application/pdf
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/antibiotics12010083
dc.relation
Antibiotics, 2023, vol. 12, p. 83
dc.relation
https://doi.org/10.3390/antibiotics12010083
dc.rights
cc-by (c) Trejo, Angela et al., 2023
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Patologia i Terapèutica Experimental)
dc.title
Efficient AntiMycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
