dc.contributor.author
Fernandez, Antonio
dc.contributor.author
Kielland, Nicola
dc.contributor.author
Makda, Ashraff
dc.contributor.author
Carragher, Neil
dc.contributor.author
González-García, M. Carmen
dc.contributor.author
Espinar-Barranco, Laura
dc.contributor.author
González-Vera, Juan Antonio
dc.contributor.author
Orte, Ángel
dc.contributor.author
Lavilla Grífols, Rodolfo
dc.contributor.author
Vendrell, Marc
dc.date.issued
2022-12-15T12:12:04Z
dc.date.issued
2022-12-15T12:12:04Z
dc.date.issued
2022-08-28
dc.date.issued
2022-12-15T12:12:04Z
dc.identifier
https://hdl.handle.net/2445/191606
dc.description.abstract
We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a library of over 60 fluorophores, we optimised compound NIRBD-62c as a multimodal probe with suitable properties for STED super-resolution and fluorescence lifetime imaging. Furthermore, we employed NIRBD-62c for imaging trafficking inside cells and to examine how pharmacological inhibitors can alter the vesicular traffic between intracellular compartments and the plasma membrane.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.1039/d2cb00168c
dc.relation
Biomedicines, 2022
dc.relation
https://doi.org/10.1039/d2cb00168c
dc.relation
info:eu-repo/grantAgreement/EC/H2020/771443/EU//DYNAFLUORS
dc.rights
cc-by (c) Fernandez, Antonio et al., 2022
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Química farmacèutica
dc.subject
Síntesi orgànica
dc.subject
Pharmaceutical chemistry
dc.subject
Organic synthesis
dc.title
A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
