dc.contributor.author
Calon, Alexandre
dc.contributor.author
Espinet, Elisa
dc.contributor.author
Palomo Ponce, Sergio
dc.contributor.author
Tauriello, Daniele V. F.
dc.contributor.author
Iglesias, Mar
dc.contributor.author
Cespedes, María Virtudes
dc.contributor.author
Sevillano, Marta
dc.contributor.author
Nadal, Cristina
dc.contributor.author
Jung, Peter
dc.contributor.author
Zhang, Xiang H. F.
dc.contributor.author
Byrom, Daniel
dc.contributor.author
Riera i Escalé, Antoni
dc.contributor.author
Rossell, David
dc.contributor.author
Mangues, Ramon
dc.contributor.author
Massagué i Solé, Joan, 1953-
dc.contributor.author
Sancho, Elena
dc.contributor.author
Batlle, Eduard
dc.date.issued
2022-02-24T19:00:57Z
dc.date.issued
2022-02-24T19:00:57Z
dc.date.issued
2014-03-05
dc.date.issued
2022-02-24T12:05:43Z
dc.identifier
https://hdl.handle.net/2445/183467
dc.description.abstract
We sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.21769/BioProtoc.1120
dc.relation
Bio-protocol, 2014, vol. 4, num. 9, p. e1120
dc.relation
https://doi.org/10.21769/BioProtoc.1120
dc.rights
(c) Bio-protocol LLC, 2014
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject
Càncer colorectal
dc.subject
Expressió gènica
dc.subject
Colorectal cancer
dc.subject
Gene expression
dc.title
Immunostaining Protocol: P-Stat3 (Xenograft and Mice)
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
