dc.contributor.author
Camilleri Robles, Carlos
dc.contributor.author
Serras Rigalt, Florenci
dc.contributor.author
Corominas, Montserrat (Corominas Guiu)
dc.date.issued
2021-04-15T09:21:50Z
dc.date.issued
2021-04-15T09:21:50Z
dc.date.issued
2019-05-18
dc.date.issued
2021-04-15T09:21:50Z
dc.identifier
https://hdl.handle.net/2445/176303
dc.description.abstract
The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/genes10050378
dc.relation
Genes, 2019, vol. 10, num. 5, p. 378
dc.relation
https://doi.org/10.3390/genes10050378
dc.rights
cc-by (c) Camilleri Robles, Carlos et al., 2019
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.title
Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
