dc.contributor.author
Ruschel Tallini, Luciana
dc.contributor.author
Torras Claveria, Laura
dc.contributor.author
Borges, Warley de Souza
dc.contributor.author
Kaiser, Marcel
dc.contributor.author
Viladomat Meya, Francesc
dc.contributor.author
Zuanazzi, José Ângelo Silveira
dc.contributor.author
Bastida Armengol, Jaume
dc.date.issued
2020-04-21T14:46:42Z
dc.date.issued
2020-04-21T14:46:42Z
dc.date.issued
2018-05-26
dc.date.issued
2020-04-21T14:46:43Z
dc.identifier
https://hdl.handle.net/2445/156462
dc.description.abstract
Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/molecules23061277
dc.relation
Molecules, 2018, vol. 23, num. 6, p. 1277
dc.relation
https://doi.org/10.3390/molecules23061277
dc.rights
cc-by (c) Ruschel Tallini, Luciana et al., 2018
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
dc.subject
Productes naturals
dc.subject
Amaril·lidàcies
dc.subject
Natural products
dc.subject
Amaryllidaceae
dc.title
N-oxide alkaloids from Crinum amabile (Amaryllidaceae)
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
