Universitat de Barcelona
2020-04-21T14:46:42Z
2020-04-21T14:46:42Z
2018-05-26
2020-04-21T14:46:43Z
Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.
Article
Published version
English
Productes naturals; Medicaments; Amaril·lidàcies; Natural products; Drugs; Amaryllidaceae
MDPI
Reproducció del document publicat a: https://doi.org/10.3390/molecules23061277
Molecules, 2018, vol. 23, num. 6, p. 1277
https://doi.org/10.3390/molecules23061277
cc-by (c) Ruschel Tallini, Luciana et al., 2018
http://creativecommons.org/licenses/by/3.0/es
