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| dc.contributor.author | Flores, José Carlos |
|---|---|
| dc.contributor.author | Gracia Lavedan, Esther |
| dc.contributor.author | Benavente, Yolanda |
| dc.contributor.author | Amiano, Pilar |
| dc.contributor.author | Romaguera, Dora |
| dc.contributor.author | Costas, Laura |
| dc.contributor.author | Robles, Claudia |
| dc.contributor.author | González Barca, Eva |
| dc.contributor.author | Banda, Esmeralda de la |
| dc.contributor.author | Alonso Sanz, Esther |
| dc.contributor.author | Aymerich Gregorio, Marta |
| dc.contributor.author | Campo Güerri, Elias |
| dc.contributor.author | Dierssen Sotos, Trinidad |
| dc.contributor.author | Marcos Gragera, Rafael |
| dc.contributor.author | Rodriguez Suarez, Marta María |
| dc.contributor.author | Solans, Marta |
| dc.contributor.author | Gimeno Vázquez, Eva |
| dc.contributor.author | Garcia Martin, Paloma |
| dc.contributor.author | Aragonès Sanz, Núria |
| dc.contributor.author | Shivappa, Nitin |
| dc.contributor.author | Hébert, James R. |
| dc.contributor.author | Pollán, Marina |
| dc.contributor.author | Kogevinas, Manolis |
| dc.contributor.author | Sanjosé Llongueras, Silvia de |
| dc.contributor.author | Castaño-Vinyals, Gemma |
| dc.contributor.author | Casabonne, Delphine |
| dc.date | 2020-01-16T12:49:33Z |
| dc.date | 2020-01-16T12:49:33Z |
| dc.date | 2019-12-23 |
| dc.date | 2020-01-15T14:10:58Z |
| dc.identifier.uri | http://hdl.handle.net/2445/148017 |
| dc.description | Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research. |
| dc.format | 15 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | MDPI AG |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.3390/nu12010048 |
| dc.relation | Nutrients, 2019, vol. 12, num. 1 |
| dc.relation | https://doi.org/10.3390/nu12010048 |
| dc.rights | cc by (c) Flores et al., 2019 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Leucèmia limfocítica crònica |
| dc.subject | Càncer |
| dc.subject | Chronic lymphocytic leukemia |
| dc.subject | Cancer |
| dc.title | The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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