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Título:	The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
Autor/a:	Flores, José Carlos; Gracia Lavedan, Esther; Benavente, Yolanda; Amiano, Pilar; Romaguera, Dora; Costas, Laura; Robles, Claudia; González Barca, Eva; Banda, Esmeralda de la; Alonso Sanz, Esther; Aymerich Gregorio, Marta; Campo Güerri, Elias; Dierssen Sotos, Trinidad; Marcos Gragera, Rafael; Rodriguez Suarez, Marta María; Solans, Marta; Gimeno Vázquez, Eva; Garcia Martin, Paloma; Aragonès Sanz, Núria; Shivappa, Nitin; Hébert, James R.; Pollán, Marina; Kogevinas, Manolis; Sanjosé Llongueras, Silvia de; Castaño-Vinyals, Gemma; Casabonne, Delphine
Notas:	Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
Materia(s):	-Leucèmia limfocítica crònica -Càncer -Chronic lymphocytic leukemia -Cancer
Derechos:	cc by (c) Flores et al., 2019 http://creativecommons.org/licenses/by/3.0/es/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	MDPI AG
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