dc.contributor.author
Solé Arjó, Daniel
dc.contributor.author
Pérez Janer, Ferran
dc.contributor.author
García-Rodeja Navarro, Yago
dc.contributor.author
Fernández Cadenas, Israel
dc.date.issued
2019-02-01T12:45:30Z
dc.date.issued
2019-02-01T12:45:30Z
dc.date.issued
2017-01-03
dc.date.issued
2019-02-01T12:45:31Z
dc.identifier
https://hdl.handle.net/2445/127810
dc.description.abstract
Sulfonates, sulfonamides, and phosphonates have proven useful nucleophiles for palladium‐catalyzed intramolecular α‐arylation reactions leading to tetrahydroisoquinolines. Although the sulfonate α‐arylation reaction can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl sulfones can be used in Michael additions when starting from sulfonamides. No domino process was developed with the phosphonate derivative. DFT calculations were carried out to gain more insights into the experimental differences observed in the reactions involving these substrates.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1002/ejoc.201601300
dc.relation
European Journal of Organic Chemistry, 2017, vol. 2017, num. 4, p. 799-805
dc.relation
https://doi.org/10.1002/ejoc.201601300
dc.rights
(c) Wiley-VCH, 2017
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Pal·ladi (Element químic)
dc.subject
Teoria del funcional de densitat
dc.subject
Síntesi orgànica
dc.subject
Density functionals
dc.subject
Organic synthesis
dc.title
Exploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
