dc.contributor.author
Sanchez-Mut, Jose Vicente
dc.contributor.author
Aso Pérez, Ester
dc.contributor.author
Heyn, Holger
dc.contributor.author
Matsuda, Tadashi
dc.contributor.author
Bock, Christoph
dc.contributor.author
Ferrer, Isidro (Ferrer Abizanda)
dc.contributor.author
Esteller, Manel
dc.date.issued
2017-05-15T10:46:29Z
dc.date.issued
2017-05-15T10:46:29Z
dc.date.issued
2017-05-15T10:46:29Z
dc.identifier
https://hdl.handle.net/2445/111024
dc.description.abstract
Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a likely candidate gene for involvement in the pathogenesis of the disorder since, as we demonstrate here, it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.1002/hipo.22245
dc.relation
Hippocampus, 2014, vol. 24, num. 4, p. 363-368
dc.relation
https://doi.org/10.1002/hipo.22245
dc.rights
cc by-nc-nd (c) Sánchez-Mut et al., 2014
dc.rights
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Ciències Fisiològiques)
dc.subject
Hipocamp (Cervell)
dc.subject
Malaltia d'Alzheimer
dc.subject
Malalties neurodegeneratives
dc.subject
Hippocampus (Brain)
dc.subject
Alzheimer's disease
dc.subject
Neurodegenerative Diseases
dc.title
Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
