dc.contributor.author
Bosch Cartes, Joan
dc.contributor.author
Bachs, Jordi
dc.contributor.author
Gómez, Antonia M.
dc.contributor.author
Griera Farres, Rosa
dc.contributor.author
Écija, Marta
dc.contributor.author
Amat Tusón, Mercedes
dc.date.issued
2017-03-03T15:44:50Z
dc.date.issued
2017-03-03T15:44:50Z
dc.date.issued
2012-07-20
dc.date.issued
2017-03-03T15:44:50Z
dc.identifier
https://hdl.handle.net/2445/107829
dc.description.abstract
Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
American Chemical Society
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1021/jo300925c
dc.relation
Journal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344
dc.relation
https://doi.org/10.1021/jo300925c
dc.rights
(c) American Chemical Society , 2012
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Antihistamínics
dc.subject
Estructura molecular
dc.subject
Síntesi orgànica
dc.subject
Antihistamines
dc.subject
Molecular structure
dc.subject
Organic synthesis
dc.title
Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
