dc.contributor.author
Merino Montero, Susana
dc.contributor.author
Gonzalez, Victor
dc.contributor.author
Tomàs Magaña, Juan
dc.date.issued
2016-12-01T15:36:43Z
dc.date.issued
2016-12-01T15:36:43Z
dc.date.issued
2015-07-10
dc.date.issued
2016-12-01T15:36:48Z
dc.identifier
https://hdl.handle.net/2445/104357
dc.description.abstract
The repeat units of heteropolymeric O antigen are synthesized at the cytosolic side of the inner bacterial membrane via the Wzx/Wzy-dependent assembly pathway. After being translocated across the membrane by Wzx, each repeat unit is polymerized by Wzy to form a glycan chain. In this study, we demonstrate the need of the corresponding enzyme trans- ferring the initial HexNAc to undecaprenol phosphate (lipid carrier), together with the corre- sponding O-antigen polymerase (Wzy), to produce the Aeromonas hydrophila O:34- antigen. We suggest, the concerted action of WecA or P enzyme (UDP-HexNAc: polypre- nol-P HexNAc-1-P transferase) and Wzy is involved in the mechanism responsible for the A . hydrophila O-antigen polymerization.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
Public Library of Science (PLoS)
dc.relation
Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131905
dc.relation
PLoS One, 2015, vol. 10, num. 7, p. e0131905
dc.relation
https://doi.org/10.1371/journal.pone.0131905
dc.rights
cc-by (c) Merino Montero, Susana et al., 2015
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject
Polimerització
dc.subject
Bacteriophages
dc.subject
Polymerization
dc.title
The polymerization of Aeromonas hydrophila AH-3 O-antigen LPS: concerted action of WecP and Wzy
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
