Universitat de Barcelona
2016-12-01T15:36:43Z
2016-12-01T15:36:43Z
2015-07-10
2016-12-01T15:36:48Z
The repeat units of heteropolymeric O antigen are synthesized at the cytosolic side of the inner bacterial membrane via the Wzx/Wzy-dependent assembly pathway. After being translocated across the membrane by Wzx, each repeat unit is polymerized by Wzy to form a glycan chain. In this study, we demonstrate the need of the corresponding enzyme trans- ferring the initial HexNAc to undecaprenol phosphate (lipid carrier), together with the corre- sponding O-antigen polymerase (Wzy), to produce the Aeromonas hydrophila O:34- antigen. We suggest, the concerted action of WecA or P enzyme (UDP-HexNAc: polypre- nol-P HexNAc-1-P transferase) and Wzy is involved in the mechanism responsible for the A . hydrophila O-antigen polymerization.
Article
Published version
English
Bacteriòfags; Transferases; Polimerització; Bacteriophages; Transferases; Polymerization
Public Library of Science (PLoS)
Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131905
PLoS One, 2015, vol. 10, num. 7, p. e0131905
https://doi.org/10.1371/journal.pone.0131905
cc-by (c) Merino Montero, Susana et al., 2015
http://creativecommons.org/licenses/by/3.0/es
