dc.contributor.author
Zanoletti, Marta
dc.contributor.author
Yaqub, Muhammad Atif
dc.contributor.author
Cortese, Lorenzo
dc.contributor.author
Buttafava, Mauro
dc.contributor.author
Martínez García, Jacqueline
dc.contributor.author
Amendola, Caterina
dc.contributor.author
Carteano, Talyta
dc.contributor.author
Frabasile, Lorenzo
dc.contributor.author
Sanoja Garcia, Diego
dc.contributor.author
Guadagno, Claudia nunzia
dc.contributor.author
Houtbeckers, Tijl
dc.contributor.author
Karadeniz, Umut
dc.contributor.author
Lacerenza, Michele
dc.contributor.author
Pagliazzi, Marco
dc.contributor.author
Parsa, Shahrzad
dc.contributor.author
Wagenaar, Tessa
dc.contributor.author
Demarteau, Luc
dc.contributor.author
Tomanik, Jakub
dc.contributor.author
Tosi, Alberto
dc.contributor.author
Weigel, Udo M
dc.contributor.author
Sekar, Sanathana Konugolu Venkata
dc.contributor.author
Torricelli, Alessandro
dc.contributor.author
Contini, Davide
dc.contributor.author
Mesquida, Jaume
dc.contributor.author
Durduran, Turgut
dc.date.accessioned
2026-03-26T08:47:57Z
dc.date.available
2026-03-26T08:47:57Z
dc.date.issued
2025-11-18
dc.identifier
Zanoletti, M. [et al.]. «hDOS» an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation. «Journal of Biomedical Optics», 18 Novembre 2025, vol. 30, núm. 11, p. 115004.
dc.identifier
https://hdl.handle.net/2117/459475
dc.identifier.uri
https://hdl.handle.net/2117/459475
dc.description.abstract
Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such as intensive care. hDOS integrates time-domain near-infrared spectroscopy, diffuse correlation spectroscopy, and pulse oximetry to assess both tissue oxygenation and perfusion. Although initially developed in the context of vascular occlusion tests, its modular design makes it suitable for broader applications, including trauma, surgery, anesthesia, and studies in healthy subjects. Aim: It aims to design and validate hDOS, focusing on precision, repeatability, and usability for peripheral microvascular monitoring in both clinical and research settings. Approach: Validation included test-retest measurements, a 7-month clinical deployment in the critical care, and a comparison with a commercial continuous wave NIRS device (INVOS 5100C). Results: The device underwent extensive validation, accumulating over 200 h of usage across similar to 150 measurement sessions. The system showed high precision (test-retest CV
dc.description.abstract
Peer Reviewed
dc.format
application/pdf
dc.relation
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-30/issue-11/115004/hDOS--an-automated-hybrid-diffuse-optical-device-for-real/10.1117/1.JBO.30.11.115004.full
dc.subject
Àrees temàtiques de la UPC::Física
dc.subject
Spectrum analysis
dc.subject
Hybrid diffuse optical system
dc.subject
Diffuse optical spectroscopy
dc.subject
Diffuse optical imaging
dc.subject
Anàlisi espectral
dc.title
"hDOS" an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation
