"hDOS" an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision and in vivo validation

Abstract

Significance: The hybrid diffuse optical system (hDOS) is a fully automated platform designed to bring advanced optical monitoring closer to clinical practice. Many existing systems lack automation, multiparametric output, and operator independence, limiting their use in demanding environments such as intensive care. hDOS integrates time-domain near-infrared spectroscopy, diffuse correlation spectroscopy, and pulse oximetry to assess both tissue oxygenation and perfusion. Although initially developed in the context of vascular occlusion tests, its modular design makes it suitable for broader applications, including trauma, surgery, anesthesia, and studies in healthy subjects. Aim: It aims to design and validate hDOS, focusing on precision, repeatability, and usability for peripheral microvascular monitoring in both clinical and research settings. Approach: Validation included test-retest measurements, a 7-month clinical deployment in the critical care, and a comparison with a commercial continuous wave NIRS device (INVOS 5100C). Results: The device underwent extensive validation, accumulating over 200 h of usage across similar to 150 measurement sessions. The system showed high precision (test-retest CV

Peer Reviewed

Document Type

Article

Language

English

Subjects and keywords

Àrees temàtiques de la UPC::Física; Spectrum analysis; Hybrid diffuse optical system; Diffuse optical spectroscopy; Diffuse optical imaging; Anàlisi espectral

Publisher

SPIE

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