dc.contributor.author
Idaghdour, Youssef
dc.date.accessioned
2026-01-09T02:05:05Z
dc.date.available
2026-01-09T02:05:05Z
dc.date.issued
2022-10-11
dc.identifier
Idaghdour, Y. Multi-omics analysis of the host immune response to malaria infection. A: Severo Ochoa Research Seminars at BSC. «8th Severo Ochoa Research Seminar Lectures at BSC, Barcelona, 2022-23». Barcelona: Barcelona Supercomputing Center, 2022, p. 18-19.
dc.identifier
https://hdl.handle.net/2117/449805
dc.identifier.uri
http://hdl.handle.net/2117/449805
dc.description.abstract
The disease burden of malaria remains a significant global
public health challenge with >600,000 deaths in 2020. Interindividual
and inter-ethnic differences in susceptibility to
malaria is multifactorial and has a significant heritable
component but our understanding of host-parasite
interactions in modulating host and parasite processes and the
course of infection remains limited. We combine the power
of longitudinal sampling of malarial children from two distinct
ethnic groups in West Africa and demonstrate the power
of host-parasite multi-omics profiling and integrative genomic
data analysis to identify the molecular perturbations taking
place in vivo in response infection. Examples of multi-omics
approaches integrating genetic, transcriptomic and
metabolomic data and the associated computational challenges
will be presented.
dc.format
application/pdf
dc.publisher
Barcelona Supercomputing Center
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.subject
Àrees temàtiques de la UPC::Informàtica::Arquitectura de computadors
dc.subject
High performance computing
dc.subject
Càlcul intensiu (Informàtica)
dc.title
Multi-omics analysis of the host immune response to malaria infection
dc.type
Conference report
