Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
2012-04
PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 mm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.
Peer Reviewed
Postprint (published version)
Article
Anglès
Àrees temàtiques de la UPC::Enginyeria dels materials; Biomedical materials; Biocompatibility; Biodegradable; Green solvents; Microparticles; Poly(lactic acid); Biomaterials
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201100383/pdf
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Restricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
E-prints [72954]