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Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission

Author

Xin-Yang, Lv

Roman, Abrams

Martin, Ruben

Publication date

2022-12-28



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Abstract

Herein, we describe the development of a copper-catalyzed C(sp3)-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.

Document Type

Article

Published version

Language

English

CDU Subject

Subject

Quimica

Pages

6 p.

Publisher

Wiley-VCH

Grant Agreement Number

FEDER/MCI PID2021-123801NB-I00

China Scholarship Council (CSC)

European Research Council (ERC) under European Union's Horizon 2020 research and innovation program (grant agreement No 883756)

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Angew Chem Int Ed - 2022 - Lv - Copper Catalyzed C sp3 Amination of Ketone Derived Dihydroquinazolinones by.pdf

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Creative Commons. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Papers [1286]