Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 281-300 de 1057
Draft genome sequences of Mycobacterium setense type strain DSM-45070 and the nonpathogenic strain Manresensis, isolated from the bank of the Cardener River in Manresa, Catalonia, Spain
We present here the draft genome sequences of two Mycobacterium setense strains. One of them corresponds to the M. setense type strain DSM-45070, originally isolated from a patient with a posttraumatic chronic skin abscess. ...
Adaptación a la altura y a ambientes fríos en personas con lesión medular
Objetivo: estudiar las diferencias en la adaptación respiratoria al ejercicio en condiciones medioambientales similares a las de la práctica de los deportes de invierno, entre personas físicamente activas y sanas con lesión ...
Neuropathology and neurochemistry of nonmotor symptoms in parkinson's disease
Parkinson disease (PD) is no longer considered a complex motor disorder characterized by Parkinsonism but rather a systemic disease with variegated non-motor deficits and neurological symptoms, including impaired olfaction, ...
Tau-positive nuclear indentations in P301S tauopathy mice
Increased incidence of neuronal nuclear indentations is a well-known feature of the striatum of Huntington's disease (HD) brains and, in Alzheimer's disease (AD), neuronal nuclear indentations have recently been reported ...
Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells
Background PPP1R6 is a protein phosphatase 1 glycogen-targeting subunit (PP1-GTS) abundant in skeletal muscle with an undefined metabolic control role. Here PPP1R6 effects on myotube glycogen metabolism, particle size and ...
Cytoskeleton-associated risk modifiers involved in early and rapid progression of sporadic Creutzfeldt-Jakob disease
A high priority in the prion field is to identify pre-symptomatic events and associated profile of molecular changes. Inthisstudy,wedemonstratethepre-symptomatic dysregulation of cytoskeleton assembly and its associated ...
Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers
Haemophilus influenzae colonizes the upper respiratory tract and can spread causing otitis and sinusitis. This work aimed to study the oropharyngeal carriage rate in healthy <5-year-old children attending day care centers ...
Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens
Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations. Site-specific mutations ...
Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights the need for intensifying research efforts devoted to developing new agents for preventing or retarding the disease process. During ...
Ultrasonographic study of the thumb pulleys and their entheses: correlations with anatomy and histology
Objectives The entheseal nature of digital annular pulleys insertion was recently described, with high resolution ultrasound (US) reliably identifying these submillimetre structures with impressive accuracy. Since the thumb ...
Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients
Background and aims: Cachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance of other classical cachexia markers. ...
Pirfenidone in post-COVID-19 pulmonary fibrosis (FIBRO-COVID): a phase 2 randomised clinical trial
Background: Patients with severe COVID-19 may develop lung fibrosis. Pirfenidone is an anti-fibrotic drug approved for idiopathic pulmonary fibrosis. The efficacy and safety of pirfenidone in patients with fibrotic ...
Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club
The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating ...
Bioactive peptides and other immunomodulators of mushroom origin
For centuries, humans have used mushrooms as both food and pro-health supplements. Mushrooms, especially those related to the functions of the human immune system, are rich in dietary fiber, minerals, essential amino acids, ...
Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease
cGAMP-specific nucleases (poxins) are a recently described family of proteins dedicated to obstructing cyclic GMP-AMP synthase signaling (cGAS), an important sensor triggered by cytoplasmic viral replication that activates ...
Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide
Objectives: Antimicrobial-resistant bacteria are a major global health threat. Mobile genetic elements (MGEs) have been crucial for spreading resistance to new bacterial species, including human pathogens. Understanding ...
Multilingual Naming
Bi/multilingualism refers to the ability to use two or more languages in everyday life. Increasing interest has been paid to unveil the neural basis of bilingual language processing; however, the brain representation of ...
Impacto de la legalización del consumo recreativo del cannabis
En los últimos años se han producido importantes cambios legislativos en numerosos países respecto al consumo de cannabis con fines medicinales y/o recreativos, que han facilitado su accesibilidad. Actualmente, Uruguay, ...
Anatomía de los ligamentos del tobillo (Comunicación oficial 1 (SECOT, Madrid, octubre 2004))
La anatomía y biomecánica de los ligamentos de tobillo sigue siendo motivo de interés pues es requisito indispensable para el diagnóstico y adecuado tratamiento de sus lesiones, ya que éstas son una de las mayores causas ...
Full-mouth periodontal examination prior to and after nonsurgical treatment in chronic periodontitis patients.
Chronic periodontitis is a pathological condition characterized by loss of the supporting tissues of the teeth. The aim of this study was to evaluate the distribution of disease sites in different areas of mouth, prior to ...
