Medicina: Envíos recientes
Mostrando ítems 1-20 de 2834
Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls
Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders ...
Protocol d'estudi prospectiu, unicèntric, doble ceg, randomitzat i Controlat amb Placebo sobre la eficacia d'una dieta baixa en histamina i suplementació amb l'enzima DAO en malalts amb intolerància a la histamina.
Background/Objectives: Histamine intolerance is primarily caused by a deficiency in the diamine oxidase (DAO) enzyme at the intestinal level. The reduced histamine degradation in the gut leads to its accumulation in plasma, ...
Higher seroprevalence of hepatitis E virus in autoimmune hepatitis: Role of false-positive antibodies
Background and aims Recent studies have found an increase in the seroprevalence of hepatitis E virus (HEV) infection in patients with autoimmune hepatitis (AIH). We aimed to assess the prevalence of positive anti-HEV IgM ...
A cross-sectional pilot study to define anal cancer risk factors in HIV-positive solid organ transplant recipients.
Background HIV-positive organ transplant recipients are at high risk of anal cancer, but there are no data on the prevalence of high-risk human papillomavirus (hr-HPV) or anal dysplasia, in this population. Objective To ...
Characteristics and outcome of acute heart failure in infective endocarditis: focus on cardiogenic shock.
Background: Studies investigating the impact of cardiogenic shock (CS) on endocarditis are lacking. Methods: Prospectively collected cohort from 35 Spanish centers (2008-2018). Logistic regression analyses were performed ...
Antidepressant use in older age bipolar disorder (OABD): Results from the GAGE-BD international consortium
Background Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of ...
Lung function predicts mortality in people with serious mental illness: A 6-year follow-up study
Background: The population with a serious mental illness (SMI) shows a high risk of premature mortality. Overexposed to multiple health risks throughout life, their main threat is physical illness, which starts earlier and ...
Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: a voxel-based diffusion tensor imaging study
Olfactory dysfunction is known to occur before the appearance of the classical motor signs in Parkinson's disease (PD) and diffusion tensor imaging (DTI) studies in PD have reported fractional anisotropy (FA) reductions ...
Current perspectives on psychedelic treatments in Europe
In this viewpoint, we explore the evolving landscape of psychedelic-assisted therapy in Europe, focusing on clinical, regulatory, and therapeutic developments. While access remains limited, recent initiatives in Switzerland, ...
General population-based lung function trajectories over the life course: an accelerated cohort study
Background Lung function is a key determinant of health, but current knowledge on lung function growth and decline over the life course is based on fragmented, potentially biased data. We aimed to empirically derive general ...
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27
Anti-HER2 antibodies are effective but often lead to resistance in patients with HER2+ breast cancer. Here, we report an epigenetic crosstalk with aberrant glycerophospholipid metabolism and inflammation as a key resistance ...
HER2DX ERBB2 mRNA score in first-line advanced HER2-positive breast cancer treated with chemotherapy, trastuzumab, and pertuzumab
In advanced HER2-positive breast cancer, the standard taxane-trastuzumab-pertuzumab (THP) regimen faces competition from new therapies, emphasizing the need for biomarkers to guide treatment. This study evaluates the ...
Workplace and non-workplace loneliness: a cross-sectional comparative study on risk factors and impacts on absenteeism and mental health among employees in Spain
Purpose The aim of this study is to (1) evaluate prevalences and concordance between workplace and non-workplace loneliness, (2) compare sociodemographic risk factors between workplace and non-workplace loneliness, (3) ...
DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder
Background: Suicidal thoughts and behaviors (STBs) are a public health issue highly prevalent in bipolar disorder (BD). Multiple factors contribute to STBs, and new evidence highlights the significant role of epigenetics, ...
Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer: Implications for Recurrence and Survival in Squamous Cell Carcinoma Patients
Despite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, in early-stage cases, recurrence after surgery continues ...
Impact of piR_004530 reactivation in lung cancer: implications for recurrence and survival of lung squamous cell carcinoma patients.
Background PIWI-interacting RNAs (piRNAs) are germline-characteristic small noncoding RNAs whose reactivation has been recently observed during carcinogenesis because of the germline reactivation program, which can be ...
CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
Background: CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify ...
Do patients with bipolar disorder and subsyndromal symptoms benefit from funcional remediation? A 12-month follow-up study
We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to ...
Interactions of cognitive reserve with regional brain anatomy and brain function during a working memory task in healthy elders
Cognitive reserve (CR) defines the capacity of the adult brain to cope with pathology in order to minimize symptomatology. Relevant lifetime social, cognitive and leisure activities represent measurable proxies of cognitive ...
Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging study
Diffusion tensor imaging (DTI) can sensitively detect white matter sex differences and the effects of pharmacological treatments. Before cross-sex hormone treatment, the white matter microstructure of several brain bundles ...
