Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL): Recent submissions
Now showing items 1-20 of 6905
Women's experiences along the ovarian cancer diganostic pathway in Catalonia: A qualitative study
Background Early detection of symptoms and prompt diagnosis of ovarian cancer are considered important avenues for improving patient experiences and outcomes. Methods This qualitative study used a phenomenological approach ...
Impact of lung cancr screening eligibility criteria on participants characteristics and healthcare resources
Selection criteria for lung cancer screening (LCS) are essential for implementing resource- and cost-efficient programs. However, different selection criteria may have similar resource requirements but select dissimilar ...
Consensus-based validation of key quality indicators in pancreatic cancer surgery in Catalonia: a modified Delphi study
ABSTRACT Introduction: Pancreatic cancer surgery is highly complex and associated with significantperioperative risk, high mortality and morbidity, low quality of life, and increased healthcarecosts. Establishing quality ...
Delays and detours during cancer diagnosis: a cross-sectional study on patient pathways and provider intervals in public healthcare networks of Chile, Colombia and Ecuador.
Background The longest delays in cancer diagnosis in Latin America occur between the first contact with health services and the confirmation of diagnosis (referred to as the provider interval), yet few studies have examined ...
Buffers in intravenous solutions: is the source of bicarbonate a source of confusion?
There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that this mechanism explains their effects on plasma pH. We aimed to explain why the effect of ...
Online Gaming Disorder and Sports Betting Addiction: Convergences and Divergences
Worldwide estimates of the prevalence of online gaming disorder (OGD) and online sports betting addiction (OSBA) have become exceedingly high, particularly among young peo- ple. The objective of this study was to compare ...
Evaluating the quality of real-world data on adherence to oral endocrine therapy in breast cancer patients: How real-world data?
Simple Summary: The objective of this study was to evaluate the validity of RWD-based adherence measurements obtained from accessible electronic health records in the Spanish national health system in all women diagnosed ...
Females and Exercise Capacity Impairment in Heart Failure: A Sex-Focused Analysis
Heart failure (HF) is becoming increasingly common, especially in older females, and displays marked sex-related differences in pathophysiology, treatment, and outcomes. Submaximal exercise capacity (SEC), frequently ...
Regulation of the orphan G-protein–coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy
Megalencephalic leukoencephalopathy with subcortical cyst (MLC) is a rare leukodystrophy primarily caused by mutations in two genes: MLC1, encoding a membrane protein of unknown function, and GlialCAM, a cell adhesion ...
Clinical Characteristics and Surgical Outcomes of Patients Receiving Perioperative Pembrolizumab in KEYNOTE-671
BACKGROUND The phase 3 KEYNOTE-671 study (NCT03425643) demonstrated significantly improved event-free survival (EFS) and overall survival with neoadjuvant pembrolizumab plus chemotherapy followed by surgery and adjuvant ...
Anatomical Validation of a Selective Anesthetic Block Test to Differentiate Morton’s Neuroma from Mechanical Metatarsalgia
Background and Objectives: The anesthetic nerve block test is a surgical technique that can assist in the differential diagnosis of forefoot pain. The MTP joint, enclosed by its capsule, may act as a sealed cavity with ...
Identification of a crosstalk between ClC-1 C-terminal CBS domains and the transmembrane region
CLC channels and transporters have large C-terminal regions which contain two cystathionine β-synthetase (CBS) domains. It has been hypothesized that conformational changes in these domains upon nucleotide binding modulate ...
Impact of beta-Lactam and Daptomycin Combination Therapy on Clinical Outcomes in Methicillin-susceptible Staphylococcus aureus Bacteremia: A Propensity Score-matched Analysis
Background. Mortality rates from Staphylococcus aureus bacteremia are high and have only modestly improved in recent decades. We compared the efficacies of a beta-lactam in combination with daptomycin (BL/D-C) and beta-lactam ...
Identification and evaluation of novel intergenic sites in the vaccinia virus genome for transgene insertion
Vaccinia virus (VACV) is widely used as a vaccine and oncolytic vector due to its safety profile and its capacity to accommodate exogenous DNA. However, its compact genome offers limited for transgene insertion without ...
Deciphering the association between morphological differences in hypothalamic subregions and circulating ghrelin and leptin concentrations: exploratory evidence in anorexia nervosa and obesity
The hypothalamus, a central regulator of hunger and metabolism, contains subnuclei responsive to peripheral signals such as leptin and ghrelin, which may be altered in anorexia nervosa (AN) and obesity (OB). This exploratory ...
Nurse Educators’ Self-Reported Level of Teaching Competence and Its Correlation with Sociodemographic, Professional, Training and Research Variables: A Cross-Sectional Multicentre Study
Nurses’ teaching skills in the clinical setting are crucial to ensuring that students receive high-quality training. Despite the growing importance of competency frameworks, there is little research on the relationship ...
Loss-of-function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5-fluorouracil and irinotecan treatment in colorectal cancer
Background: Colorectal cancer (CRC) remains a major global health concern, partly due to resistance to therapy and the lack of new effective treatments for advanced disease. The combination of 5-Fluorouracil (5FU, a ...
XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists ...
XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (II)
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists ...
Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases
Colorectal cancer (CRC) frequently develops aggressive metastatic disease, yet the cellular features that enable dissemination remain poorly defined. IKK alpha, a kinase traditionally linked to stress and inflammatory ...
