Palbociclib and letrozole for hormone receptor-positive HER2-negative breast cancer with residual disease after neoadjuvant chemotherapy 

Pernas, Sònia; Sanfeliu, Esther; Villacampa, Guillermo; Salvador, Javier; Perelló, Antonia; González, Xavier; Jiménez, Begoña; Merino, María; Palacios, Patricia; Pascual, Tomás; Alba, Emilio; Villanueva, Lorea; Chillara, Samyukta; Ferrero Cafiero, Juan Manuel; Galvan, Patricia; Prat Aparicio, Aleix; Ciruelos, Eva (Publication date: 2025-03-04)

With the incorporation of cyclin-dependent kinase inhibitors in early breast cancer (BC), a better identification of biomarkers is needed. The PROMETEO II trial aimed to evaluate the antitumor activity of palbociclib plus ...

Evaluation of a Mixing versus a Cycling Strategy of Antibiotic Use in Critically-Ill Medical Patients: Impact on Acquisition of Resistant Microorganisms and Clinical Outcomes 

Cobos-Trigueros, Nazaret; Solé, Mar; Castro, Pedro; Torres, Jorge Luis; Rinaudo, Mariano; Lazzari, Elisa de; Morata, Laura; Hernández-Munain, Cristina; Fernández, Sara (Fernández García); Soriano Viladomiu, Alex; Nicolás Arfelis, Josep Maria; Mensa Pueyo, Josep; Vila Estapé, Jordi; Martínez, José Antonio (Martínez Martínez) (Publication date: 2016-05-19)

OBJECTIVE: To compare the effect of two strategies of antibiotic use (mixing vs. cycling) on the acquisition of resistant microorganisms, infections and other clinical outcomes. METHODS: ...

Scoring sleep in neurodegenerative diseases: A pilot study in the synucleinopathies 

Montini, Angelica; Iranzo, Alex; Cortelli, Pietro; Gaig Ventura, Carles; Muñoz Lopetegi, Amaia; Provini, Federica; Santamaria, Joan (Publication date: 2024-03-04)

Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer's disease 

Contador Muñana, José Miguel; Pérez Millan, Agnès; Tort Merino, Adrià; Balasa, Mircea; Falgàs Martínez, Neus; Olives Cladera, Jaume; Castellvi, Magda; Lladó Plarrumaní, Albert; Bosch Capdevila, Beatriz; Fernández Villullas, Guadalupe; Ramos Campoy, Oscar; Antonell Boixader, Anna, 1978-; Bargalló Alabart, Núria; Sanchez del Valle Díaz, Raquel; Sala Llonch, Roser; Lladó Plarrumaní, Albert (Publication date: 2024-07-05)

There is evidence longitudinal atrophy in posterior brain areas in early-onset Alzheimer's disease (EOAD; aged < 65 years), but no studies have been conducted in an EOAD cohort with fluid biomarkers characterization. We ...

Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study 

Ferrer Fábrega, Joana; Folch i Puy, Emma; Lozano Salvatella, Juan José; Ventura Aguiar, Pedro; Cárdenas, Gabriel; Paredes, David; García Criado, Ángeles; Bombí, Josep Antoni; García Pérez, Rocío; López Boado, Miguel Ángel; Rull, Ramón; Esmatjes Mompó, Enric; Ricart Brulles, Ma. José; Diekmann, Fritz; Fondevila Campo, Constantino; Fernández Cruz, Laureano; Fuster Obregón, Josep; García-Valdecasas Salgado, Juan Carlos (Publication date: 2022-05-13)

Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas ...

Glucocorticoids promote transition of ductal carcinoma in situ to invasive ductal carcinoma by inducing myoepithelial cell apoptosis 

Zubeldia Plazaola, Arantzazu; Recalde Percaz, Leire; Moragas, Núria; Alcaraz, Mireia; Chen, Xieng; Mancino, Mario; Fernández Nogueira, Patricia; Prats de Puig, Miquel; Guzman, Flavia; Noguera Castells, Aleix; López Plana, Anna; Enreig, Estel; Carbó Carbó, Neus; Almendro Navarro, Vanessa; Gascón, Pere; Bragado, Paloma; Fuster Orellana, Gemma (Publication date: 2019-05-10)

BACKGROUND: The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast cancer and, particularly, in myoepithelial cell ...

Outcomes of corticosteroid therapy in patients with viral community-acquired pneumonia 

Cillóniz, Catia; Guzzardella, Amedeo; Calabretta, David; Gabarrús Barri, Albert; Marcos, María Ángeles; Torres Martí, Antoni (Publication date: 2025-04-30)

Aim: The objective of this study was to assess the therapeutic effects of corticosteroids in adult patients hospitalized with viral community-acquired pneumonia. Methods: This is a retrospective analysis of data collected ...

Viral enhancer mimicry of host innate-immune promoters 

Kropp, Kai Alexander; Angulo Aguado, Ana; Ghazal, Peter (Publication date: 2017-07-14)

The inflammatory milieu is the natural habitat for a pathogenic infection, characterised by activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry rapidly activates a range of innate-immune ...

Clinical presentations and antibody mechanisms in anti-IgLON5 disease 

Gaig Ventura, Carles; Sabater Baudet, Lidia (Publication date: 2025-02-11)

Anti-IgLON5 disease is a rare neurological disease, identified just ten years ago, where autoimmunity and neurodegeneration converge. The heterogeneity of symptoms, sometimes mimicking pure neurodegenerative diseases or ...

Reduced fractalkine levels lead to striatal synaptic plasticity deficits in Huntington's disease 

Kim, Anya; García-García, Esther; Straccia, Marco; Comella Bolla, Andrea; Miguez, Andrés; Masana Nadal, Mercè; Alberch i Vié, Jordi, 1959-; Canals i Coll, Josep M.; Rodríguez Allué, Manuel José (Publication date: 2020-10-16)

Huntington's disease (HD) is an inherited neurodegenerative disorder in which the striatum is the most affected brain region. Although a chronic inflammatory microglial reaction that amplifies disease progression has been ...

Incidence, morbidity and mortality, and management of acute coronary syndrome during the time of COVID-19 lockdown 

Echarte Morales, Julio; Minguito Carazo, Carlos; Cepas Guillen, Pedro Luis; Vallejo García, Víctor; Poveda Pinedo, Isabel Dolores; Martínez Gómez, Eduardo; Sánchez Muñoz, Enrique; López Benito, María; Salazar Rodríguez, Anthony; Cruz González, Ignacio; Arbas Redondo, Emilio; Benito González, Tomás; Guzmán Bofarull, Joan; Tebar Márquez, Daniel; Viana Tejedor, Ana; Sánchez Fernández, Pedro Luis; Sabaté, Manel; Fernández Vázquez, Felipe (Publication date: 2023-10-16)

During the lockdown due to the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a decrease in the number of admissions due to acute coronary syndrome (ACS) was observed. The objective ...

Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug. 

Schenk, Hannah C. M.; Gille, Ilse; Arana, Carolt; Rovira Juárez, Jordi; Palou, Eduard; Diekmann, Fritz; Roelen, Dave L.; Heemskerk, Mirjam H. M.; Heidt, Sebastiaan (Publication date: 2026-01-27)

Initially, chimeric antigen receptor (CAR) T-cell therapy was developed to eliminate malignant B cells in haematological B-cell malignancies by targeting CD19 and B-cell maturation antigen. This approach achieved notable ...

Premature Ovarian Insufficiency: The Spanish Menopause Society (AEEM) and the European Society of Gynecology (ESG) position statement  

Castelo-Branco Flores, Camil; Guinot Gasull, Misericordia; Baquedano Mainar, Laura; Cancelo Hidalgo, María J.; Cano, Antonio; Gil Arribas, Elisa; Lobo Martínez, Sonia; Llaneza Suárez, Cristina; Llaneza Coto, Plácido; Mendoza Ladrón de Guevara, Nicolás; Perelson del Pozo, Irene; Quereda, Francisco; Roca Comella, Beatriz; Romagosa, Carla; Romero Duarte, Pablo; Chabbert-Buffet, Nathalie; Serfaty, David; Genazzani Andrea (Publication date: 2026-01-14)

Premature ovarian insufficiency (POI) is an uncommon condition affecting 1–2% of women younger than 40, 1 in 1,000 in their thirties and 1 in 10,000 under 20 years of age. The multiple etiologies of this clinical condition ...

Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents 

Fernández de Larrea Rodríguez, Carlos José; Cibeira López, Maria Teresa; Tovar Gomis, Natalia; Cibeira, Maria Teresa; Aróstegui Gorospe, Juan Ignacio; Rosiñol Dachs, Laura; Elena, Montserrat; Filella Pla, Xavier; Yagüe Ribes, Jordi; Bladé, J. (Joan) (Publication date: 2026-01-27)

The emergence of oligoclonal bands is associated with a favorable outcome after autologous stem cell transplantation in multiple myeloma. The aim of this study was to determine the prevalence of immunoglobulin oligoclonality ...

Extracorporeal photopheresis for refractory BK virus-associated nephropathy in kidney transplantation 

Escudero-Saiz, Victor J.; Xipell Font, Marc; Gonzalez Rojas, Ángela; Rodriguez Espinoza, Diana María; Cacho, Judit; Arana Aliaga, Carolt; Piñeiro, Gastón Julio; Ventura Abreu Aguiarà, Pedro; Rovira Juárez, Jordi; Larque, Ana B.; Charry, Paola; Cid Vidal, Joan; Oppenheimer, Federico; Bodro, Marta; Lozano Molero, Miguel; Diekmann, Fritz (Publication date: 2026-01-30)

Background BK virus-associated nephropathy (BKVAN) remains an important risk factor for kidney graft loss. The current strategy to treat the BKVAN consists in reducing immunosuppressants. However, this strategy increases ...

Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy. 

Sebastiani, Giorgia; Navarro Tapia, Elisabet; Almeida Toledano, Laura; Serra Delgado, Mariona; Paltrinieri, Anna Lucia; García Algar, Óscar; Andreu Fernández, Vicente (Publication date: 2025-06-13)

During pregnancy, cycles of hypoxia and oxidative stress play a key role in the proper development of the fetus. Hypoxia during the first weeks is crucial for placental development, while the increase in oxygen due to the ...

Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons. 

Sancho Balsells, Anna; Borràs Pernas, Sara; Brito, Verónica; Alberch i Vié, Jordi, 1959-; Girault, Jean-Antoine; Giralt Torroella, Albert (Publication date: 2024-02-15)

We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. ...

Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation of Glutathione Metabolism in Livers from Patients with Alcoholic Hepatitis 

Manchel, Alexandra; Mahadevan, Radhakrishnan; Bataller Alberola, Ramón; Hoek, Jan B.; Vadigepalli, Rajanikanth (Publication date: 2024-03-25)

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there is no efficacious treatment aiding most patients. AH manifests differently in individuals, with some patients showing debilitating ...

YKT6 expression, exosome release, and survival in non-small cell lung cancer 

Ruíz Martínez, Marc; Navarro Ponz, Alfons; Marrades Sicart, Ramon Ma.; Viñolas Segarra, Núria; Santasusagna, Sandra; Muñoz García, Carmen; Ramírez Ruz, J. (José); Molins López-Rodó, Laureano; Monzó Planella, Mariano (Publication date: 2017-01-02)

BACKGROUND: Cancer-derived exosomes are involved in metastasis. YKT6 is a SNARE protein that participates in the regulation of exosome production and release, but its role in non-small cell lung cancer (NSCLC) has not been ...

Clinical Genetics of Inherited Arrhythmogenic Disease in the Pediatric Population 

Martínez Barrios, Estefanía; César Diaz, Sergio; Cruzalegui, José; Hernández Cera, Clara; Arbelo, Elena; Fiol, Victoria; Brugada, Ramon; Brugada Terradellas, Josep, 1958-; Campuzano Larrea, Oscar; Sarquella Brugada, Georgia (Publication date: 2023-06-21)

Sudden death is a rare event in the pediatric population but with a social shock due to its presentation as the first symptom in previously healthy children. Comprehensive autopsy in pediatric cases identify an inconclusive ...