Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome 

Álvarez Lerma, Francisco; Marín Corral, Judith; Vila, Clara; Masclans, Joan Ramon; González de Molina, Francisco Javier; Martín Loeches, Ignacio; Barbadillo, Sandra; Rodríguez, Alejandro; Torres Martí, Antoni; Cillóniz, Catia; H1N1 GETGAG/SEMICYUC Study Group (Fecha de publicación: 2019-11-12)

Background: Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a ...

Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes 

Cobo Cobo, María Teresa; Kacerovsky, Marian; Palacio, Montse; Hornychova, Helena; Hougaard, David M.; Skogstrand, Kristin; Jacobsson, Bo (Fecha de publicación: 2018-10-04)

Background To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of ...

Clinical significance and applications of oscillometry 

Kaminsky, David A.; Simpson, Shannon J.; Berger, Kenneth I.; Calverley, Peter M.; De Melo, Pedro L.; Dandurand, Ronald; Dellacà, Raffaele L.; Farah, Claude S.; Farré Ventura, Ramon; Hall, Graham L.; Ioan, Iulia; Irvin, Charles G.; Kaczka, David W.; King, Gregory G.; Kurosawa, Hajime; Lombardi, Enrico; Maksym, Geoffrey N.; Marchal, François; Oostveen, Ellie; Oppenheimer, Beno W.; Robinson, Paul D.; Van den Berge, Maarten; Thamrin, Cindy (Fecha de publicación: 2023-08-28)

Recently, 'Technical standards for respiratory oscillometry' was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, ...

The synovial and blood monocyte DNA methylomes mirror prognosis, evolution and treatment in early arthritis 

Calle Fabregat, Carlos de la; Rodriguez Ubreva, J.; Ciudad, L.; Ramírez, J.; Celis, R.; Azuaga, A. B.; Cuervo, A.; Graell, E.; Pérez Garcia, Carolina; Diaz Torne, C.; Salvador, G.; Gomez Puerta, J. A.; Haro, I.; Sanmartí Sala, Raimon; Canete, J. D.; Ballestar Tarín, Esteban (Fecha de publicación: 2024-03-25)

Identifying predictive biomarkers at early stages of early inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with arthritis, are ...

Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells 

Pereira, Inês Sousa; López Martínez, María José; Villasante, Aranzazu; Introna, Clelia; Tornero, Daniel; Canals i Coll, Josep M.; Samitier i Martí, Josep (Fecha de publicación: 2023-03-20)

Introduction: Three-dimensional (3D) bioprinting is a promising technique for the development of neuronal in vitro models because it controls the deposition of materials and cells. Finding a biomaterial that supports neural ...

Genetic and Epigenetic Associations with Pre-Chronic Obstructive Pulmonary Disease Lung Function Trajectories 

Martino, David J.; Bui, Dinh S.; Li, Shuai; Idrose, Sabrina; Perret, Jennifer; Lowe, Adrian J.; Lodge, Caroline J.; Bowatte, Gayan; Moodley, Yuben; Thomas, Paul S.; Zosky, Graeme; Hansbro, Philip M.; Holloway, John W.; Svanes, Cecilie; Faner, Rosa; Walters, Eugene H.; Dharmage, Shyamali C. (Fecha de publicación: 2024-02-27)

Understanding the molecular mechanisms of lung function trajectories that progress to chronic obstructive pulmonary disease (COPD) (pre-COPD trajectories), especially those with a rapidly declining phenotype, should inform ...

Evidence of brain injury in fetuses of mothers with preterm labor with intact membranes and preterm prelabor rupture of membranes. 

Murillo Bravo, Clara; Eixarch Roca, Elisenda; Rueda Ricarte, Claudia; Larroya Solà, Marta; Boada, David; Grau, Laia; Ponce Vilà, Júlia; Aldecoa, Victoria; Monterde Puente, Elena; Ferrero Martínez, Silvia; Andreu Fernández, Vicente; Arca Díaz, Gemma; Oleaga Zufiría, Laura; Ros, Olga; Hernández, Maria Pilar; Gratacós Solsona, Eduard; Palacio, Montse; Cobo Cobo, María Teresa (Fecha de publicación: 2025-01-14)

Brain injury and poor neurodevelopment have consistently been reported in infants and adults born preterm. These changes occur at least in part prenatally and are associated with intra-amniotic inflammation. The pattern ...

Bespoken nanoceria: A new effective treatment in experimental hepatocellular carcinoma 

Fernández Varo, Guillermo; Perramón Corominas, Meritxell; Carvajal Romero, Silvia; Oró Bozzini, Denise; Casals, Eudald; Boix i Ferrero, Loreto; Oller, Laura; Macías-Muñoz, Laura; Marfà Bruix, Santiago; Casals Mercadal, Gregori; Morales Ruiz, Manuel; Casado, Pedro; Cutillas, Pedro R.; Bruix Tudó, Jordi; Navasa, Miquel; Fuster Obregón, Josep; García-Valdecasas Salgado, Juan Carlos; Pavel, Mihai; Puntes, Víctor; Jiménez Povedano, Wladimiro (Fecha de publicación: 2021-03-15)

Background and aims: Despite the availability of new-generation drugs, hepatocellular carcinoma (HCC) is still the third most frequent cause of cancer-related deaths worldwide. Cerium oxide nanoparticles (CeO2 NPs) have ...

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials 

Garcia Medina, Jose Javier; Rubio Velazquez, Elena; Foulquie Moreno, Elisa; Casaroli Marano, Ricardo Pedro; Pinazo Durán, María Dolores; Zanon Moreno, Vicente; Rio Vellosillo, Monica del (Fecha de publicación: 2021-04-19)

Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. ...

Differences in peripheral and tissue immune cell populations following haematopoietic stem cell transplantation in Crohn's disease patients 

Corraliza Márquez, Ana Maria; Ricart, Elena; López-García, Alicia; Masamunt, Maria Carme; Veny Alvarez-Ossorio, Marisol; Esteller, Manel; Mayorgas, Aida; Le Bourhis, Lionel; Allez, Matthieu; Planell Picola, Núria; Visvanathan, Sudha; Baum, Patrick; España, Carolina; Cabezón Cabello, Raquel; Benítez-Ribas, Daniel; Rovira Tarrats, Montserrat; Panés Díaz, Julià; Salas Martínez, Azucena (Fecha de publicación: 2020-04-20)

Background and aims: recent studies have shown the efficacy of autologous haematopoietic stem cell transplantation [HSCT] in severely refractory Crohn's disease [CD] patients. HSCT is thought to eliminate auto-reactive ...

Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units 

Mesquida, Jaume; Caballer, Alba; Cortese, Lorenzo; Vilà, Clara; Karadeniz, Umut; Pagliazzi, Marco; Zanoletti, Marta; Pérez Pacheco, Argelia; Castro Rebollo, Pedro; García-de-Acilu, Marina; Mesquita, Rickson Coelho; Busch, David R.; Durduran, Turgut; HEMOCOVID-19 Consortium (Fecha de publicación: 2022-05-31)

Background: COVID-19 is primarily a respiratory disease; however, there is also evidence that it causes endothelial damage in the microvasculature of several organs. The aim of the present study is to characterize in vivo ...

Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy 

Garcia Pouton, Nicol; Ortiz-Maldonado Gibson, Valentín; Peyrony, Oliver; Chumbita, Mariana; Aiello, Tommaso Francesco; Monzó Gallo, Patricia; Lopera, Carlos; Puerta-Alcalde, Pedro; Magnano, Laura; Martínez Cibrian, Nuria; Pitart, Cristina; Juan, Manel; Delgado, Julio; Fernández de Larrea Rodríguez, Carlos José; Soriano Viladomiu, Alex; Urbano Ispizua, Álvaro; Garcia Vidal, Carolina (Fecha de publicación: 2024-01-24)

Role of joint aspiration before re-implantation in patients with a cement spacer in place 

Huguet, Sandra; Bernaus, Martí; Gómez, Lucía; Cuchí, Eva; Soriano Viladomiu, Alex; Font Vizcarra, Lluís (Fecha de publicación: 2023-05-12)

The usefulness of a mandatory joint aspiration before re-implantation in patients with a cement spacer already in place is unclear.To evaluate the role of culturing synovial fluid obtained by joint aspiration before ...

Novel Decellularization Method for Tissue Slices 

Narciso, Maria; Ulldemolins Iglesias, Anna; Júnior, Constança; Otero Díaz, Jorge; Navajas Navarro, Daniel; Farré Ventura, Ramon; Gavara i Casas, Núria; Almendros López, Isaac (Fecha de publicación: 2022-06-07)

Decellularization procedures have been developed and optimized for the entire organ or tissue blocks, by either perfusion of decellularizing agents through the tissue’s vasculature or submerging large sections in decellularizing ...

Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer's disease (ALFASleep project): protocol for an observational study 

Fauria, Karine; Minguillón, Carolina; Knezevic, Iva; Tort Colet, Núria; Stankeviciute, Laura; Hernández, Laura; Radoi, Andreea; Deulofeu, Carme; Fuentes Julián, Sherezade; Turull, Israel; Fusté, David; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Suárez Calvet, Marc; Holst, Sebastian C.; Garcés, Pilar; Mueggler, Thomas; Zetterberg, Henrik; Blennow, Kaj; Arqueros, Aurora; Iranzo, Alex; Gispert, Juan Domingo; Molinuevo, José Luis; Grau Rivera, Oriol (Fecha de publicación: 2023-07-24)

The growing worldwide prevalence of Alzheimer's disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised ...

Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030 

Estes, Chris; Anstee, Quentin M.; Arias Loste, Maria Teresa; Bantel, Heike; Bellentani, Stefano; Caballeria Rovira, Joan; Colombo, Massimo; Craxi, Antonio; Crespo, Javier; Day, Christopher P.; Eguchi, Yuichiro; Geier, Andreas; Kondili, Loreta A.; Kroy, Daniela C.; Lazarus, Jeffrey V.; Loomba, Rohit; Manns, Michael P.; Marchesini, Giulio; Nakajima, Atsushi; Negro, Francesco; Petta, Salvatore; Ratziu, Vlad; Romero-Gómez, Manuel; Sanyal, Arun; Schattenberg, Jörn M.; Tacke, Frank; Tanaka, Junko; Trautwein, Christian; Wei, Lai; Zeuzem, Stefan; Razavi, Homie (Fecha de publicación: 2019-06-05)

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis and hepatocellular carcinoma globally. This burden is expected to increase as ...

Aggressive Course in Encephalitis With Opsoclonus, Ataxia, Chorea, and Seizures. The First Pediatric Case of γ-Aminobutyric Acid Type B Receptor Autoimmunity 

Kruer, Michael C.; Höftberger, Romana; Lim, Kit Yeng; Coryell, Jason C.; Svoboda, Melissa D.; Woltjer, Randall L.; Dalmau Obrador, Josep (Fecha de publicación: 2018-02-07)

IMPORTANCE: Autoantibodies to the γ-aminobutyric acid type B (GABAB) receptor have recently been identified as a cause of autoimmune encephalitis. Most patients with GABAB encephalitis have presented with limbic encephalitis. ...

Cryptic Insertions Of The Immunoglobulin Light Chain Enhancer Region Near CCND1 In T(11;14)-Negative Mantle Cell Lymphoma 

Fuster, Carla; Martín García, David; Balagué, Olga; Navarro, Alba; Nadeu Prat, Ferran; Costa, Dolors; Prieto, Miriam; Salaverria Frigola, Itziar; Espinet Solà, Blanca; Rivas Delgado, Alfredo; Terol, Maria José; Giné Soca, Eva; Forcada, Pilar; Ashton-Key, Margaret; Puente, Xose S.; Swerdlow, Steven H.; Beà Bobet, Sílvia M.; Campo Güerri, Elias (Fecha de publicación: 2020-03-03)

Cyclin D1+ mantle cell lymphoma (MCL) is molecularly characterized by the t(11;14)(q13;q32) or rearrangements of CCND1 gene with the immunoglobulin (IG) light chains.1,2 Most MCL can be diagnosed based on the characteristic ...

Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona 

Sisó Almirall, Antoni; Kostov, Belchin; Mas Heredia, Minerva; Vilanova Rotllan, Sergi; Sequeira Aymar, Ethel; Sans Corrales, Mireia; Sant Arderiu, Elisenda; Cayuelas Redondo, Laia; Martinez Pérez, Angela; Garcia Plana, Noemi; Anguita Guimet, August; Benavent Àreu, Jaume (Fecha de publicación: 2022-03-17)

Background In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community. Aim To determine clinical factors ...

A machine learning-based transcriptomic signature for predicting tumor recurrence after curative resection in T1 colorectal cancer: a retrospective multicenter cohort study (The Tw1CE trial). 

Noma, Takayuki; Daca Alvarez, Maria de los Angeles; San Juan, Xavier; Ibáñez, Gemma; Musulén, Eva; Goel, Ajay (Fecha de publicación: 2026-02-16)

T1 colorectal cancer (T1 CRC) is increasingly treated with curative-intent endoscopic resection, but tumor recurrence remains a critical factor influencing patient prognosis. However there is no validated biomarker exists ...