IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer: Recent submissions
Now showing items 41-60 of 3164
Current perspectives on psychedelic treatments in Europe
In this viewpoint, we explore the evolving landscape of psychedelic-assisted therapy in Europe, focusing on clinical, regulatory, and therapeutic developments. While access remains limited, recent initiatives in Switzerland, ...
General population-based lung function trajectories over the life course: an accelerated cohort study
Background Lung function is a key determinant of health, but current knowledge on lung function growth and decline over the life course is based on fragmented, potentially biased data. We aimed to empirically derive general ...
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27
Anti-HER2 antibodies are effective but often lead to resistance in patients with HER2+ breast cancer. Here, we report an epigenetic crosstalk with aberrant glycerophospholipid metabolism and inflammation as a key resistance ...
HER2DX ERBB2 mRNA score in first-line advanced HER2-positive breast cancer treated with chemotherapy, trastuzumab, and pertuzumab
In advanced HER2-positive breast cancer, the standard taxane-trastuzumab-pertuzumab (THP) regimen faces competition from new therapies, emphasizing the need for biomarkers to guide treatment. This study evaluates the ...
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming
Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in a controlled spatiotemporal manner in two ...
Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids
Introduction: Patient-derived organoids have emerged as a promising in vitro model for precision medicine, particularly in cancer, but also in noncancer-related diseases. However, the optimal culture medium for culturing ...
DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder
Background: Suicidal thoughts and behaviors (STBs) are a public health issue highly prevalent in bipolar disorder (BD). Multiple factors contribute to STBs, and new evidence highlights the significant role of epigenetics, ...
Corpus callosum atrophy in adolescents with antecedents of moderate perinatal asphyxia
Background: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy (HIE) causes callosal ...
Impact of piR_004530 reactivation in lung cancer: implications for recurrence and survival of lung squamous cell carcinoma patients.
Background PIWI-interacting RNAs (piRNAs) are germline-characteristic small noncoding RNAs whose reactivation has been recently observed during carcinogenesis because of the germline reactivation program, which can be ...
CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
Background: CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify ...
Do patients with bipolar disorder and subsyndromal symptoms benefit from funcional remediation? A 12-month follow-up study
We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to ...
Human microglia-like cells differentiated from monocytes with GM-CSF and IL-34 show phagocytosis of α-synuclein aggregates and C/EBPβ-dependent proinflammatory activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial ...
Interactions of cognitive reserve with regional brain anatomy and brain function during a working memory task in healthy elders
Cognitive reserve (CR) defines the capacity of the adult brain to cope with pathology in order to minimize symptomatology. Relevant lifetime social, cognitive and leisure activities represent measurable proxies of cognitive ...
Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging study
Diffusion tensor imaging (DTI) can sensitively detect white matter sex differences and the effects of pharmacological treatments. Before cross-sex hormone treatment, the white matter microstructure of several brain bundles ...
Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease
Cognitive reserve (CR) is the brain's capacity to cope with cerebral damage to minimize clinical manifestations. The 'passive model' considers head or brain measures as anatomical substrates of CR, whereas the 'active ...
Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients
Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural ...
Olfactory dysfunction after subarachnoid haemorrhage caused by ruptured aneurysms of the anterior communicating artery.
Object Olfactory dysfunction has an important impact on quality of life. In patients with subarachnoid hemorrhage (SAH), anosmia has mainly been reported after surgery for aneurysms of the anterior communicating artery ...
Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI
Background: Brain areas interact mutually to perform particular complex brain functions such as memory or language. Furthermore, under resting-state conditions several spatial patterns have been identified that resemble ...
Nuclear stiffness through lamin A/C overexpression differentially modulates chromosomal instability biomarkers
Background Information Mitosis is crucial for the faithful transmission of genetic material, and disruptions can result in chromosomal instability (CIN), a hallmark of cancer. CIN is a known driver of tumor heterogeneity ...
Polo-like kinase 1 inhibitors in refractory colorectal cancer: deciphering the myth of synthetic lethality
Metastatic colorectal cancer (mCRC) remains a highly lethal disease because resistance to chemotherapy and targeted agents—including anti-VEGF and anti-EGFR therapies—emerges rapidly and universally. In RAS‑mutant mCRC, ...
