Peripartum lithium management: Early maternal and neonatal outcomes 

Imaz, M.Luisa; Torra, Mercè; Langohr, Klaus; Arca Díaz, Gemma; Soy Muner, Dolors; Hernández, Ana Sandra; García Esteve, Luisa; Vieta i Pascual, Eduard, 1963-; Martín Santos, Rocío (Publication date: 2024-10-09)

Background: It has been suggested that a 30-50% lithium dose reduction or lithium discontinuation 24-48h before delivery could minimize neonatal complications. We investigated the maternal lithemia changes around delivery ...

Simple low-cost construction and calibration of accurate pneumotachographs for monitoring mechanical ventilation in low-resource settings 

Farré Ventura, Ramon; Rodríguez Lázaro, Miguel A.; Gozal, David; Trias, Gerard; Solana, Gorka; Navajas Navarro, Daniel; Otero Díaz, Jorge (Publication date: 2024-01-31)

Assessing tidal volume during mechanical ventilation is critical to improving gas exchange while avoiding ventilator-induced lung injury. Conventional flow and volume measurements are usually carried out by built-in ...

The stress-inducible protein DRR1 exerts distinct effects on actin dynamics 

Kretzschmar, Anja; Schülke, Jan-Philip; Masana Nadal, Mercè; Dürre, Katharina; Müller, Marianne B.; Bausch, Andreas R.; Rein, Theo (Publication date: 2020-04-20)

Cytoskeletal dynamics are pivotal to memory, learning, and stress physiology, and thus psychiatric diseases. Downregulated in renal cell carcinoma 1 (DRR1) protein was characterized as the link between stress, actin dynamics, ...

Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease 

Canal de la Iglesia, Mercè; Martín Flores, Núria; Pérez Sisqués, Leticia; Romaní Aumedes, Joan; Altas, Bekir; Man, Heng-Ye; Kawabe, Hiroshi; Alberch i Vié, Jordi, 1959-; Malagelada Grau, Cristina (Publication date: 2017-02-02)

Parkinson's disease (PD) is a disorder characterized by the degeneration of certain neuronal populations in the central and peripheral nervous system. One of the hallmarks of the disease is the toxic accumulation of proteins ...

Passive stiffness of left ventricular myocardial tissue is reduced by ovariectomy in a post-menopause mouse model 

Farré, Núria; Jorba, Ignasi; Torres, Marta; Falcones, Bryan; Martí Almor, Julio; Farré Ventura, Ramon; Almendros López, Isaac; Navajas Navarro, Daniel (Publication date: 2019-12-10)

Background: Heart failure (HF) - a very prevalent disease with high morbidity and mortality - usually presents with diastolic dysfunction. Although post-menopause women are at increased risk of HF and diastolic dysfunction, ...

Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection 

Claret i Carles, Marc; Pozo, Macarena (Publication date: 2019-12-05)

Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular ...

Evaluation of the Effects of CCN4 on Pancreatic Beta Cell Proliferation 

Fernández Ruiz, Rebeca; Gasa, Rosa (Publication date: 2024-02-26)

Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis 

Juanola, Adrià; Graupera, Isabel; Elia, Chiara; Piano, Salvatore; Solé, Cristina; Carol, Marta; Pérez-Guasch, Martina; Bassegoda, Octavi; Escudé, Laia; Rubio, Ana Belén; Cervera, Marta; Napoleone, Laura; Avitabile, Emma; Ma, Ann T.; Fabrellas i Padrès, Núria; Pose Méndez, Elisa; Morales Ruiz, Manuel; Jiménez Povedano, Wladimiro; Torres, Ferran; Crespo Conde, Gonzalo; Solà, Elsa; Ginès i Gibert, Pere (Publication date: 2024-11-13)

Background & aims: Decompensated cirrhosis (DC) is associated with high mortality, mainly owing to the development of acute-on-chronic liver failure (ACLF). Identifying the patients with DC who are at high risk of mortality ...

What to expect and when: benznidazole toxicity in chronic Chagas' disease treatment 

Aldasoro, Edelweiss; Posada, Elizabeth; Requena-Méndez, Ana; Calvo-Cano, Antonia; Serret, N.; Casellas, Aina; Sanz, Sergi; Soy Muner, Dolors; Pinazo, Maria-Jesus; Gascón i Brustenga, Joaquim (Publication date: 2018-02-26)

Background: Benznidazole is one of the two most effective antiparasitic drugs for Chagas' disease treatment. However, knowledge about its toxicity profile is mostly based on ...

Genetic predisposition to chronic lymphocytic leukemia is mediated by a BMF super-enhancer polymorphism 

Kandaswamy, Radhika; Sava, Georgina P.; Speedy, Helen E.; Beà Bobet, Sílvia M.; Martín-Subero, José Ignacio; Studd, James B.; Migliorini, Gabriele; Law, Philip J.; Puente, Xose S.; Martín García, David; Salaverria Frigola, Itziar; Gutiérrez-Abril, Jesús; López-Otin, Carlos; Catovsky, Daniel; Allan, James M.; Campo Güerri, Elias; Houlston, Richard S. (Publication date: 2018-02-09)

Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which ...

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function 

Boutant, Marie; Joffraud, Magali; Kulkarni, Sameer S.; García-Casarrubios, Ester; García-Roves, Pablo M. (Pablo Miguel); Ratajczak, Joanna; Fernández-Marcos, Pablo J.; Valverde, Ángela M.; Serrano Marugán, Manuel; Cantó, Carles (Publication date: 2017-02-09)

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, ...

Device for negative pressure wound therapy in low-resource regions: open-source description and bench test evaluation 

Farré Ventura, Ramon; Rodriguez-Lazaro MA; González Martín, Julián; Castro, Pedro; Hospital, Teresa; Compta, Yaroslau; Solana, Gorka; Gozal, David; Otero Díaz, Jorge (Publication date: 2022-11-23)

Background: Negative (vacuum) pressure therapy promotes wound healing. However, commercially available devices are unaffordable to most potential users in low- and middle-income countries (LMICs), limiting access to many ...

Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection 

Schaapman, Jelte J.; Amorós, Àlex; Reijden, Johan J. van der; Laleman, Wim; Zeuzem, Stefan; Bañares, Rafael; Jalan, Rajiv; Arroyo, Vicente; Clària i Enrich, Joan; Verspaget, Hein W.; Coenraad, Minneke J. (Publication date: 2020-05-12)

BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating ...

Burnout in residents during the first wave of the COVID-19 pandemic: a systematic review and meta-analysis 

Navinés, Ricard; Olive, Victoria; Hidalgo Mazzei, Diego; Langohr, Klaus; Vieta i Pascual, Eduard, 1963-; Martín Santos, Rocío (Publication date: 2025-04-03)

Introduction: The high prevalence of burnout in resident physicians is expected to have increased as a result of the expansion of the pandemic. We conducted a systematic review with a meta-analysis of studies conducted ...

Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients 

Coloma, José Luis; Martínez Zamora, María Ángeles; Tàssies Penella, María Dolores; Reverter Calatayud, Juan Carlos; Espinosa Garriga, Gerard; Cervera i Segura, Ricard, 1960-; Carmona Herrera, Francisco (Publication date: 2024-02-06)

Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in ...

Unlocking doors without keys: activation of Src by truncated C-terminal intracellular receptor tyrosine kinases lacking tyrosine kinase activity 

Mezquita Mas, Betlem; Mezquita, Pau; Pau, Montserrat; Mezquita Pla, Jovita; Mezquita Pla, Cristóbal (Publication date: 2018-05-15)

One of the best examples of the renaissance of Src as an open door to cancer has been the demonstration that just five min of Src activation is sufficient for transformation and also for induction and maintenance of cancer ...

Exploring the genetics of lithium response in bipolar disorders. 

Herrera-Rivero, Marisol; Adli, Mazda; Akiyama, Kazufumi; Akula, Nirmala; Amare, Azmeraw T.; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Michel; Backlund, Lena; Bellivier, Frank; Benabarre, Antonio; Bengesser, Susanne; Bhattacharjee, Abesh Kumar; Biernacka, Joanna M.; Birner, Armin; Cearns, Micah; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Caterina; Cichon, Sven; Clark, Scott R.; Colom, Francesc; Cruceanu, Cristiana; Czerski, Piotr M.; Dalkner, Nina; Degenhardt, Franziska; Zompo, Maria del; DePaulo, J. Raymond; Etain, Bruno; Falkai, Peter; Ferensztajn-Rochowiak, Ewa; Forstner, Andreas J.; Frank, Josef; Frisén, Louise; Frye, Mark A.; Fullerton, Janice M.; Gallo, Carla; Gard, Sébastien; Garnham, Julie S.; Goes, Fernando S.; Grigoroiu-Serbanescu, Maria; Gro, Paul; Hashimoto, Ryota; Hasler, Roland; Hauser, Joanna; Heilbronner, Urs; Herms, Stefan; Hoffmann, Per; Hou, Liping; Hsu, Yi-Hsiang; Jamain, Stephane; Jimenez, Esther; Kahn, Jean-Pierre; Kassem, Layla; Kato, Tadafumi; Kelsoe, John; Kittel-Schneider, Sarah; Kuo, Po-Hsiu; Kusumi, Ichiro; König, Barbara; Laje, Gonzalo; Landén, Mikael; Lavebratt, Catharina; Leboyer, Marion; Leckband, Susan G.; Maj, Mario; Manchia, Mirko; Marie-Claire, Cynthia; Martinsson, Lina; McCarthy, Michael J.; McElroy, Susan L.; Millischer, Vincent; Mitjans Niubó, Marina; Mondimore, Francis M.; Monteleone, Palmiero; Nievergelt, Caroline M.; Novák, Tomas; Nöthen, Markus M.; O'Donovan, Claire; Ozaki, Norio; Papiol, Sergi; Pfennig, Andrea; Pisanu, Claudia; Potash, James B.; Reif, Andreas; Reininghaus, Eva; Richard-Lepouriel, Hélène; Roberts, Gloria; Rouleau, Guy A.; Rybakowski, Janusz K.; Schalling, Martin; Schofield, Peter R.; Schubert, Klaus Oliver; Schulte, Eva C.; Schweizer, Barbara W.; Severino, Giovanni; Shekhtman, Tatyana; Shilling, Paul D.; Shimoda, Katzutaka; Simhandl, Christian; Slaney, Claire M.; Squassina, Alessio; Stamm, Thomas; Stopkova, Pavla; Streit, Fabian; Tekola-Ayele, Fasil; Thalamuthu, Anbupalam; Tortorella, Alfonso; Turecki, Gustavo; Veeh, Julia; Vieta i Pascual, Eduard, 1963-; Viswanath, Biju; Witt, Stephanie H.; Zandi, Peter P.; Alda, Martin; Bauer, Michael; McMahon, Francis J.; Mitchell, Philip B.; Rietschel, Marcella; Schulze, Thomas G.; Baune, Bernhard T. (Publication date: 2025-12-23)

Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been ...

Transient platelet hyporesponsiveness in non-ischemic arrhythmogenic cardiac arrest after achieving restoration of spontaneous circulation in pigs. 

Magaldi, Marta; Giron, Gabriela O.; Radike, Monika; Ramos-Regalado, Lisaidy; Alcover, Sebastia; Otero, Sergi; Catalina, Pablo; Canovas, Maria Angeles; Vendrell, Marina; Dantas, Ana Paula; Gorog, Diana Adrienne; Padro, Teresa; Borrell, Maria; Badimon, Lina; Peray Bruel, Claudia de; Vilahur, Gemma (Publication date: 2026-02-26)

This study shows that variable and often attenuated platelet reactivity after CA, together with neutral OHCA outcome data argues against indiscriminate antiplatelet loading before the cause of shock is clarified. For ...

Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients 

Martín Varillas, José Luis; Sánchez Bilbao, Lara; Calvo Río, Vanesa; Adán Civera, Alfredo; Hernanz, Inés; Gallego Flores, Adela; Beltran Catalan, Emma; Castro Oreiro, Sonia; Fanlo, Patricia; García Martos, Álvaro; Torre, Ignacio; Cordero Coma, Miguel; Dios, Juan Ramón de; García Aparicio, Ángel; Hernández Garfella, Marisa; Sánchez Andrade, Amalia; García Valle, Andrea; Maiz Alonso, Olga; Miguélez, Roberto; Rodríguez Montero, Sergio; Urruticoechea Arana, Ana; Veroz, Raúl; Conesa, Arantxa; Fernéndez Carballido, Cristina; Jovaní, Vega; Mondejar, José J.; Martínez González, Olga; Moya Alvarado, Patricia; Romero Yuste, Susana; Rubio Muñoz, Paula; Peña Sainz-Pardo, Eva; Garijo Bufort, Marta; Demetrio Pablo, Rosalía; Hernández, José L.; Blanco, Ricardo (Publication date: 2024-03-27)

Objectives: To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID).MethodsMulticentre study of CZP-treated patients with IMID uveitis refractory to ...

Clinical, Endoscopic, and Histological Characteristics of Severe Immune Checkpoint Inhibitor-Induced Colitis 

Casas Deza, Diego; Polo Cuadro, Cristina; Gascón Ruiz, Marta; Barreiro-de Acosta, Manuel; Mañosa, Míriam; Rodríguez-moranta, Francisco; Zabana, Yamile; Céspedes Martínez, Elena; Ordás, Ingrid; Miranda Bautista, José; José García, María; García De La Filia Molina, Irene; Roig Ramos, Cristina; Ruiz Cerulla, Alexandra; Segarra-ortega, José Xavier; Matallana Royo, Virginia; Rodríguez González, Esther; Martínez De Juan, Fernando; Manceñido Marcos, Noemí; Madero Velázquez, Lucía; Betoré Glaría, Elena; Álvarez Herrero, Begoña; Suris, Gerard; Garrido Marín, Alejandro; Brunet Mas, Eduard; Alonso Abreu, Inmaculada; Santos Fernández, Javier; Vaamonde Lorenzo, María; Almingol Crespo, Cristina; Folguera, Carla; Sanz Segura, Patricia; Moralejo Lozano, Óscar; López Couceiro, Laura; Tejido Sandoval, Coral; Mena Sánchez, Raquel; Sainz, Empar; Marquès-camí, Miquel; Ferreiro-iglesias, Rocío; Ortega Moya, Silvia Patricia; Wolfe García, Pablo Miles; Borras Garriga, Pere; Herreros Martínez, Belén; Calvo Iñiguez, María; Frago Larramona, Santiago; Ladrón Abia, Pablo; Serra-ruiz, Xavier; Menchén, Luis; Rivas Rivas, Coral; Mesonero Gismero, Francisco; Vicente Lidón, Raquel; Gutierrez, Ana; García López, Santiago (Publication date: 2026-02-23)

Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. They can cause immune-mediated colitis (IMC), a potentially severe adverse event. Current data on severe IMC (grade 3-4) are limited, ...