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IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer: Recent submissions

Now showing items 301-320 of 3164

    IL-15 Enhances the Persistence and Function of BCMA-Targeting CAR-T Cells Compared to IL-2 or IL-15/IL-7 by Limiting CAR-T Cell Dysfunction and Differentiation 

    Battram, Anthony M.; Bachiller, Mireia; López Díaz, Víctor; Fernández de Larrea Rodríguez, Carlos José; Urbano Ispizua, Álvaro; Martin-Antonio, Beatriz (Publication date: 2026-01-28)

    Simple Summary T cells modified with a chimeric antigen receptor (CAR) that targets BCMA, a protein expressed on malignant plasma cells, represent a novel treatment option for multiple myeloma. Despite initially eliminating ...

    Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition 

    Granell, Miquel; Calvo, Xavier; Garcia Guinon, Antoni; Escoda, Lourdes; Abella, Eugènia; Martinez, Clara Mª; Teixido, Montserrat; Gimenez, Mª Teresa; Senín, Alicia; Sanz, Patricia; Campoy, Desirée; Vicent, Ana; Arenillas, Leonor; Rosiñol Dachs, Laura; Sierra, Jorge; Bladé, J. (Joan); Fernández de Larrea Rodríguez, Carlos José; GEMMAC (Grup per l'estudi del mieloma i l'amiloïdosi de Catalunya) (Publication date: 2026-01-28)

    The presence of circulating plasma cells in patients with multiple myeloma is considered a marker for highly proliferative disease. In the study herein, the impact of circulating plasma cells assessed by cytology on survival ...

    Cortical thinning is associated with disease stages and dementia in Parkinson's Disease 

    Zarei, Mohammad; Ibarretxe Bilbao, Naroa; Compta, Yaroslau; Hough, Morgan; Junqué i Plaja, Carme, 1955-; Bargalló Alabart, Núria; Tolosa, Eduardo; Martí Domènech, Ma. Josep (Publication date: 2026-01-30)

    Objective: To investigate the pattern of cortical thinning in Parkinson's disease (PD) across different disease stages and to elucidate to what extent cortical thinning is related to cognitive impairment. Design: Ninety-six ...

    Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study 

    Wagstyl, Konrad; Whitaker, Kirstie; Raznahan, Armin; Seidlitz, Jakob; Vértes, Petra E; Foldes, Stephen; Humphreys, Zachary; Hu, Wenhan; Mo, Jiajie; Likeman, Marcus; Davies, Shirin; Lenge, Matteo; Cohen, Nathan T; Tang, Yingying; Wang, Shan; Ripart, Mathilde; Chari, Aswin; Tisdall, Martin; Bargalló Alabart, Núria; Conde Blanco, Estefanía; Pariente, Jose Carlos; Pascual-Diaz, Saül; Delgado-Martínez, Ignacio; Pérez-Enríquez, Carmen; Lagorio, Ilaria; Abela, Eugenio; Mullatti, Nandini; O'Muircheartaigh, Jonathan; Vecchiato, Katy; Liu, Yawu; Caligiuri, Maria; Sinclair, Ben; Vivash, Lucy; Willard, Anna; Kandasamy, Jothy; McLellan, Ailsa; Sokol, Drahoslav; Semmelroch, Mira; Kloster, Ane; Opheim, Giske; Yasuda, Clarissa; Zhang, Kai; Hamandi, Khalid; Barba, Carmen; Guerrini, Renzo; Gaillard, William Davis; You, Xiaozhen; Wang, Irene; González Ortiz, Sofía; Severino, Mariasavina; Striano, Pasquale; Tortora, Domenico; Kalviainen, Reetta; Gambardella, Antonio; Labate, Angelo; Desmond, Patricia; Lui. Elaine; O'Brien, Terry; Shetty, Jay; Jackson, Graeme; Duncan, John S; Winston, Gavin P; Pinborg, Lars; Cendes, Fernando; Cross, Judith Helen; Baldeweg, Torsten; Adler, Sophie (Publication date: 2026-01-26)

    Objective: Drug-resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and ...

    Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 

    Ortega, Natalia; Ribes, Marta; Vidal, Marta; Rubio, Rocío; Aguilar, Ruth; Williams, Sarah; Barrios, Diana; Alonso, Selena; Hernández-Luis, Pablo; Mitchell, Robert A.; Jairoce, Chenjerai; Cruz, Angeline; Jiménez, Alfons; Santano, Rebeca; Méndez, Susana; Lamoglia Puig, Montserrat; Rosell, Neus; Llupià García, Anna; Puyol, Laura; Chi, Jordi; Rodrigo-Melero, Natalia; Parras, Daniel; Serra, Pau; Pradenas Saavedra, Edwards; Trinité, Benjamin; Blanco, Julià; Mayor Aparicio, Alfredo Gabriel; Barroso, Sonia; Varela, Pilar; Vilella, Anna; Trilla Garcia, Antonio De Padua; Santamaria, Pere; Carolis, Carlo; Tortajada, Marta; Izquierdo Lázaro, Luis; Angulo Aguado, Ana; Engel Rocamora, Pablo; Garcia-Basteiro, Alberto L; Moncunill Piñas, Gemma; Dobaño, Carlota, 1969- (Publication date: 2026-01-14)

    Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential ...

    Risk of partial school closure for COVID-19 by socio-economic level in the period 2020-22 

    Pericas, Carles; Avcii, Gülcan; Baena Díez, José Miguel; Domínguez García, Àngela; Toledo Zavaleta, Diana Isabel; Redondo, Ana; Vilaplana Carnerero, Carles; Grau, Maria (Publication date: 2026-01-21)

    Background. The objective was to analyse the risk of partial school closure by economic level in Barcelona city.Methods In this ecological study, the risk of partial school closure for the academic years 2020-21 and 2021-22 ...

    Early Antiretroviral Therapy Not Associated With Higher Cryptococcal Meningitis Mortality in People With Human Immunodeficiency Virus in High-Income Countries: An International Collaborative Cohort Study 

    Teira, Ramon; Saag, Michael S.; Crane, Heidi M.; Moore, Richard D.; Jacobson, Jeffrey M.; Mathews, W. Chris; Geng, Elvin; Eron, Joseph J.; Althoff, Keri N.; Kroch, Abigail; Brandes, Vanessa; Lang, Raynell; Bucher, Heiner C.; Gill, M. John; Sabin, Caroline; Sterne, Jonathan A. C.; Vidal Marsal, Francisco; Obel, Niels; Mocroft, Amanda; Wittkop, Linda; D'Arminio Monforte, Antonella; Torti, Carlo; Mussini, Cristina; Ingle, Suzanne M.; Miró Meda, José M. (José María), 1956-; May, Margaret T.; Cain, Lauren E.; Schwimmer, Christine; Zangerle, Robert; Sambatakou, Helen; Cazanave, Charles; Reiss, Peter; Furrer, Hansjakob; Konopnicki, Deborah (Publication date: 2026-01-28)

    Background Randomized controlled trials (RCTs) from low- and middle-income settings suggested that early initiation of antiretroviral therapy (ART) leads to higher mortality rates among people with HIV (PWH) who present ...

    Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia 

    Boel, Judith A; MDS Study Group Mild Cognitive Impairment in Parkinson's Disease; de Bie, Rob M A; Schmand, Ben A; Dalrymple-Alford, John C; Marras, Connie; Adler, Charles H; Goldman, Jennifer G; Tröster, Alexander I; Burn, David J; Litvan, Irene; Geurtsen, Gert J (Publication date: 2026-01-13)

    Background: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown. Methods: ...

    Latent representation of H&E images retains biological information in a breast cancer cohort 

    Benmussa, Chloé; Sanfeliu, Esther; Martínez Romero, Anabel; González Farré, Blanca; Pascual, Tomás; Gavilá, Joaquín; Levy-Jurgenson, Alona; Shamir, Ariel; Brasó Maristany, Fara; Prat Aparicio, Aleix; Yakhini, Zohar (Publication date: 2026-01-23)

    Imaging technologies and staining based pathology are important components of common practice cancer care. Specifically, H&E imaging is standard for almost all cancer patients. Traditionally, H&E images can serve, when ...

    Risk factors in severe anaphylaxis: which matters the most, food or cofactors? 

    Casas Saucedo, Rocio; Cruz, Cinthia de la; Araujo Sánchez, Giovanna; Gelis, Sònia; Jimenez, T.; Riggioni, S.; San Bartolome, Clara; Pascal i Capdevila, Mariona; Bartra Tomàs, Joan; Muñoz-Cano, Rosa (Publication date: 2026-03-02)

    Background: The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients ...

    Emergence of oligoclonal bands in patients with multiple myeloma in complete remission after induction chemotherapy: association with the use of novel agents 

    Fernández de Larrea Rodríguez, Carlos José; Cibeira López, Maria Teresa; Tovar Gomis, Natalia; Cibeira, Maria Teresa; Aróstegui Gorospe, Juan Ignacio; Rosiñol Dachs, Laura; Elena, Montserrat; Filella Pla, Xavier; Yagüe Ribes, Jordi; Bladé, J. (Joan) (Publication date: 2026-01-27)

    The emergence of oligoclonal bands is associated with a favorable outcome after autologous stem cell transplantation in multiple myeloma. The aim of this study was to determine the prevalence of immunoglobulin oligoclonality ...

    Influence of myocardial scar on the response to frequent premature ventricular complex ablation 

    Penela, Diego; Martinez, Mikel; Fernández Armenta, Juan; Aguinaga, Luis; Tercedor, Luis; Ordóñez, Augusto; Acosta, Juan; Martí Almor, Julio; Bisbal, Felipe; Rossi, Luca; Borràs, Roger; Linhart, Markus; Soto Iglesias, David; Jáuregui Garrido, Beatriz; Ortiz Pérez, José Tomás; Perea Palazón, Rosario Jesús; Bosch Genover, Xavier; Mont Girbau, Lluís; Berruezo Sánchez, Antonio (Publication date: 2026-01-09)

    Objective This study aims to evaluate the influence of myocardial scar after premature ventricular complexes (PVC) ablation in patients with left ventricular (LV) dysfunction. Methods 70 consecutive patients (58±11 years, ...

    Marked Variation in Hepatic Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Over 5 Years: A Community-Based Study Using Controlled Attenuation Parameter 

    Cervera, Marta; Pérez-Guasch, Martina; Carol, Marta; Nadal, Ruth; Sanz-Rodríguez, María; Juanola, Adrià; Soria, Anna; Hernández, Rosario; Sáez, Gemma; Pellón, Míriam; Herms, Queralt; Pose Méndez, Elisa; Ginès, Pere; Graupera, Isabel; Fabrellas i Padrès, Núria (Publication date: 2026-01-22)

    Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is very common and associated with significant morbidity and mortality due to its potential progression to cirrhosis and liver cancer. Whereas ...

    Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug. 

    Schenk, Hannah C. M.; Gille, Ilse; Arana, Carolt; Rovira Juárez, Jordi; Palou, Eduard; Diekmann, Fritz; Roelen, Dave L.; Heemskerk, Mirjam H. M.; Heidt, Sebastiaan (Publication date: 2026-01-27)

    Initially, chimeric antigen receptor (CAR) T-cell therapy was developed to eliminate malignant B cells in haematological B-cell malignancies by targeting CD19 and B-cell maturation antigen. This approach achieved notable ...

    Extracorporeal photopheresis for refractory BK virus-associated nephropathy in kidney transplantation 

    Escudero-Saiz, Victor J.; Xipell Font, Marc; Gonzalez Rojas, Ángela; Rodriguez Espinoza, Diana María; Cacho, Judit; Arana Aliaga, Carolt; Piñeiro, Gastón Julio; Ventura Abreu Aguiarà, Pedro; Rovira Juárez, Jordi; Larque, Ana B.; Charry, Paola; Cid Vidal, Joan; Oppenheimer, Federico; Bodro, Marta; Lozano Molero, Miguel; Diekmann, Fritz (Publication date: 2026-01-30)

    Background BK virus-associated nephropathy (BKVAN) remains an important risk factor for kidney graft loss. The current strategy to treat the BKVAN consists in reducing immunosuppressants. However, this strategy increases ...

    Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study. 

    Martínez, Ester; Foncillas, Alberto; Téllez, Adrián; Fernández, Sara; Martínez-Nadal, Gemma; Rico, Verónica; Tomé, Adrià; Ugarte, Ainoa; Rinaudo, Mariano; Berrocal, Leire; De Lazzari, Elisa; Miró Meda, José M.; Nicolás Arfelis, Josep Maria; Mallolas Masferrer, Josep; De la Mora, Lorena; Castro Rebollo, Pedro (Publication date: 2026-02-12)

    Purposes: Since 2016, the World Health Organization has recommended universal antiretroviral therapy (ART) for all people living with Human Immunodeficiency Virus (PLHIV). This recommendation may have influenced the ...

    Premature Ovarian Insufficiency: The Spanish Menopause Society (AEEM) and the European Society of Gynecology (ESG) position statement  

    Castelo-Branco Flores, Camil; Guinot Gasull, Misericordia; Baquedano Mainar, Laura; Cancelo Hidalgo, María J.; Cano, Antonio; Gil Arribas, Elisa; Lobo Martínez, Sonia; Llaneza Suárez, Cristina; Llaneza Coto, Plácido; Mendoza Ladrón de Guevara, Nicolás; Perelson del Pozo, Irene; Quereda, Francisco; Roca Comella, Beatriz; Romagosa, Carla; Romero Duarte, Pablo; Chabbert-Buffet, Nathalie; Serfaty, David; Genazzani Andrea (Publication date: 2026-01-14)

    Premature ovarian insufficiency (POI) is an uncommon condition affecting 1–2% of women younger than 40, 1 in 1,000 in their thirties and 1 in 10,000 under 20 years of age. The multiple etiologies of this clinical condition ...

    Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts 

    Dobaño, Carlota, 1969-; Alonso, Selena; Vidal, Marta; Jiménez, Alfons; Rubio, Rocío; Santano, Rebeca; Barrios, Diana; Pons Tomàs, Gemma; Melé Casas, Maria; Hernández García, María; Girona Alarcón, Mònica; Puyol, Laura; Baro, Bàrbara; Millat Martínez, Pere; Ajanovic, Sara; Balanza Lombardia, Núria; Arias, Sara; Rodrigo Melero, Natalia; Carolis, Carlo; García Miquel, Aleix; Bonet Carné, Elisenda; Claverol, Joana; Cubells, Marta; Fortuny Guasch, Claudia; Fumadó, Victoria; Codina, Anna; Bassat Orellana, Quique; Muñoz Almagro, Carmen; Fernández de Sevilla Estrach, Mariona; Gratacós Solsona, Eduard; Izquierdo Lázaro, Luis; García García, Juan José; Aguilar, Ruth; Jordán García, Iolanda; Moncunill Piñas, Gemma (Publication date: 2022-06-20)

    COVID-19 affects children to a lesser extent than adults but they can still get infected and transmit SARS-CoV-2 to their contacts. Field deployable non-invasive sensitive diagnostic techniques are needed to evaluate the ...

    Chronic Obstructive Pulmonary Disease and Lung Cancer: A Review for Clinicians 

    Criner, Gerard J.; Agustí García-Navarro, Àlvar; Borghaei, Hossein; Friedberg, Joseph; Martinez, Fernando J.; Miyamoto, Curtis; Vogelmeier, Claus F.; Celli, Bartolome R. (Publication date: 2023-05-29)

    Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are common global causes of morbidity and mortality. Because both diseases share several predisposing risks, the two diseases may occur concurrently in ...

    Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis 

    Mullol i Miret, Joaquim; Izquierdo, Iñaki; Okubo, Kimihiro; Canonica, Giorgio Walter; Bousquet, Jean; Valero, Antonio (Publication date: 2020-03-03)

    Background: Diferent clinical trials showed the superior efcacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically ...