Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis 

Baldwin, Helen; Radua, Joaquim; Antoniades, Mathilde; Haas, Shalaila S.; Frangou, Sophia; Agartz, Ingrid; Allen, Paul; Andreassen, Ole A.; Atkinson, Kimberley; Bachman, Peter; Baeza, Inmaculada; Bartholomeusz, Cali F.; Chee, Michael W. L.; Colibazzi, Tiziano; Cooper, Rebecca E.; Corcoran, Cheryl M.; Cropley, Vanessa L.; Ebdrup, Bjørn H.; Fortea, Adriana; Glenthøj, Louise Birkedal; Hamilton, Holly K.; Haut, Kristen M.; Hayes, Rebecca A.; He, Ying; Heekeren, Karsteen; Kaess, Michael; Kasai, Kiyoto; Katagiri, Naoyuki; Kim, Minah; Kindler, Jochen; Klaunig, Mallory J.; Koike, Shinsuke; Koppel, Alex; Kristensen, Tina D.; Bin Kwak, Yoo; Kwon, Jun Soo; Lawrie, Stephen M.; Lebedeva, Irina; Lee, Jimmy; Lin, Ashleigh; Sugranyes, Gisela; Fusar Poli, Paolo; ENIGMA Clinical High Risk for Psychosis Working Group (Data de publicació: 2024-01-24)

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. ...

Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma 

Fernández Bertolín, Laura; Mullol i Miret, Joaquim; Fuentes Prado, Mireya; Roca i Ferrer, Jordi; Alobid, Isam; Picado Vallés, César; Pujols Tarrés, Laura (Data de publicació: 2020-06-17)

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the upper airways frequently associated with asthma. Bacterial infection is a feature of CRSwNP that can aggravate the disease and the ...

Transcriptional Profile Associated with Clinical Outcomes in Metastatic Hormone-Sensitive Prostate Cancer Treated with Androgen Deprivation and Docetaxel 

Jimenez, Natalia; Reig Torras, Oscar; Marin Aguilera, Mercedes; Aversa, Caterina; Ferrer Mileo, Laura; Font, Albert; Rodriguez Vida, Alejo; Climent, Miguel Ángel; Cros, Sara; Chirivella, Isabel; Domenech, Montserrat; Figols, Mariona; González Billalabeitia, Enrique; Jiménez Peralta, Daniel; Rodriguez Carunchio, Leonardo; Garcia Esteve, Samuel; García de Herrero, Marta; Ribal, María José; Prat Aparicio, Aleix; Mellado González, Begoña (Data de publicació: 2023-04-27)

Background: Androgen deprivation therapy (ADT) and docetaxel (DX) combination is a standard therapy for metastatic hormone-sensitive prostate cancer (mHSPC) patients. (2) Methods: We investigate if tumor transcriptomic ...

El corazón de las personas que nacieron con bajo peso podría ser distinto del de los demás 

Crispi Brillas, Fàtima; Sepúlveda-Martínez, Álvaro; Rodríguez-Lopez, Merida (Data de publicació: 2022-11-09)

Si durante el embarazo el feto experimenta una falta de nutrientes, intentará ahorrar y engordará menos. Sin embargo, esto puede tener importantes consecuencias en su salud adulta.

Lowering Portal Pressure Improves Outcomes of Patients With Cirrhosis, With or Without Ascites: A Meta-Analysis 

Turco, Laura; Villanueva, Càndid; Mura, Vincenzo La; García Pagán, Juan Carlos; Reiberger, Thomas; Genescà, Joan; Groszmann, Roberto J.; Sharma, Barjesh C.; Merkel, Carlo; Bureau, Christophe; Alvarado Tapias, Edilmar; González-Abraldes Iglesias, Juan; Albillos, Agustín; Bañares, Rafael; Peck-Radosavljevic, Markus; Augustin, Salvador; Sarin, Shiv K.; Bosch, Jaime; García-Tsao, Guadalupe (Data de publicació: 2020-01-20)

Background & Aims: In unselected patients with cirrhosis, those with reductions in hepatic venous pressure gradient (HVPG) to below a defined threshold (responders) have a reduced risk of variceal hemorrhage (VH) and death. ...

Diagnóstico endoscópico de la infección por H. pylori 

Garcés Durán, Rodrigo Vicente; Llach Roca, Joan; Da Fieno, Angella; Córdova, Henry; Fernández Esparrach, Gloria (Data de publicació: 2023-10-23)

[spa] La infección por Helicobacter pylori (H. pylori) es muy prevalente en nuestro medio, y se asocia a enfermedad gástrica muy relevante, tanto benigna como maligna. El patrón oro para su diagnóstico sigue siendo, a día ...

Extracorporeal Photopheresis Improves Graft Survival in a Full-Mismatch Rat Model of Kidney Transplantation 

Piñeiro, Gastón Julio; Lazo Rodríguez, Marta; Ventura Abreu Aguiarà, Pedro; Ramírez Bajo, María José; Bañón Maneus, Elisenda; Lozano Molero, Miguel; Cid Vidal, Joan; Hierro García, Natalia; Cucchiari, David; Revuelta Vicente, Ignacio; Montagud Marrahi, Enrique; Palou Ribera, Eduard; Bayés Genís, Beatriz Enriqueta; Campistol Plana, Josep M.; Diekmann, Fritz; Rovira Juárez, Jordi (Data de publicació: 2025-11-14)

Extracorporeal photopheresis (ECP) is an immunomodulatory therapy based on the infusion of autologous cellular products exposed to ultraviolet light (UV) in the presence of a photosensitizer. The study evaluates the ECP ...

Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma 

Bachert, Claus; Hellings, Peter W.; Mullol i Miret, Joaquim; Naclerio, Robert M.; Chao, Jingdong; Amin, Nikhil; Grabher, Annette; Swanson, Brian N.; Hamilton, Jennifer D.; Guillonneau, Sophie; Christine Taniou; Zhang, Donghui; Pirozzi, Gianluca; Graham, Neil M. H.; Staudinger, Heribert; Mannent, Leda P.; Khan, Asif (Data de publicació: 2020-03-03)

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, ...

Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker 

Terra, Ximena; Ceperuelo Mallafré, Victoria; Merma, Carla; Benaiges, Ester; Bosch, Ramon; Castillo, Paola; Flores, Joan Carles; Leon, Xavier; Valduvieco, Izaskun; Baste, Neus; Camara, Marina; Lejeune, Marylene; Guma, Josep; Vendrell, Joan; Vilaseca, Isabel; Fernandez Veledo, Sonia; Avilés Jurado, Francesc Xavier (Data de publicació: 2022-03-04)

Simple Summary: Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous ...

WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes 

Wallings, Rebecca L.; Hughes, Laura P.; Staley, Hannah A.; Simon, Zachary D.; McFarland, Nikolaus R.; Alcalay, Roy N.; Garrido, Alicia; Martí Domènech, Ma. Josep; Tolosa, Eduardo; Dzamko, Nicolas; Gámez Tansey, Malú (Data de publicació: 2024-04-02)

Both leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are promising targets for the treatment of Parkinson's disease (PD). Evidence suggests that both proteins are involved in biological pathways involving ...

Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study 

Madeira Miranda, Cláudia; Ferreira Lisboa da Silva, Rose Mary; Peruhybe Magalhães, Vanessa; Brugada Terradellas, Josep, 1958- (Data de publicació: 2023-06-21)

Vasovagal syncope (VVS) is the most common cause of syncope. Some stages of its pathophysiological mechanisms remain unclear. Vasoactive substances such as nitric oxide metabolites (NOx) and endothelin (ET) may be involved ...

IL-23 (Interleukin-23)-producing conventional dendritic cells control the detrimental IL-17 (Interleukin-17) response in stroke 

Gelderblom, Mathias; Gallizioli, Mattia; Ludewig, Peter; Thom, Vivien; Arunachalam, Priyadharshini; Rissiek, Björn; Bernreuther, Christian; Glatzel, Markus; Korn, Thomas; Arumugam, Thiruma Valavan; Sedlacik, Jan; Gerloff, Christian; Tolosa, Eva; Planas Obradors, Anna Maria; Magnus, Tim (Data de publicació: 2020-12-04)

Background and Purpose—Inflammatory mechanisms can exacerbate ischemic tissue damage and worsen clinical outcome in patients with stroke. Both αβ and γδ T cells are established mediators of tissue damage in stroke, and the ...

Mechanism-Based Modeling of Perioperative Variations in Hemoglobin Concentration in Patients Undergoing Laparoscopic Surgery 

Jaramillo Selman, Sebastián; Marco Ariño, Nicolás; Montane Muntane, Mar; Blasi Ibáñez, Annabel; Navarro Ripoll, Ricard; Peray Bruel, Claudia de; Vila Cullell, Isabel; Gambús, Pedro L.; Trocóniz, Iñaki F. (Data de publicació: 2024-02-16)

Hemoglobin concentration ([Hb]) in the perioperative setting should be interpreted in the context of the variables and processes that may affect it to differentiate the dilution effects caused by changes in intravascular ...

Leigh syndrome is the main clinical characteristic of PTCD3 deficiency 

Muñoz Pujol, Gerard; Ortigoza Escobar, Juan D.; Paredes Fuentes, Abraham José; Jou, Cristina; Ugarteburu López, Olatz; Gort, Laura; Yubero, Delia; Garcia Cazorla, Angels; O'Callaghan, Mar; Campistol Plana, Jaume; Muchart, Jordi.; Yépez, Vicente A.; Gusic, Mirjana; Gagneur, Julien; Prokisch, Holger; Artuch Iriberri, Rafael; Ribes Rubió, Maria Antònia; Urreizti, Roser; Tort, Frederic (Data de publicació: 2024-02-19)

Mitochondrial translation defects are a continuously growing group of disorders showing a large variety of clinical symptoms including a wide range of neurological abnormalities. To date, mutations in PTCD3, encoding a ...

Ceftobiprole for the treatment of pneumonia 

Cillóniz, Catia; Dominedò, Cristina; Garcia Vidal, Carolina; Torres Martí, Antoni (Data de publicació: 2019-11-25)

Ceftobiprole is a fifth-generation cephalosporin with potent antimicrobial activity against Gram positive and Gram-negative bacteria. It has been approved in major European countries for the treatment of community-acquired ...

The molecular hallmarks of primary and secondary vitreoretinal lymphoma 

Bonzheim, Irina; Sander, Philip; Salmerón Villalobos, Julia; Süsskind, Daniela; Szurman, Peter; Gekeler, Florian; Spitzer, Martin S.; Steinhilber, Julia; Kohler, Esther; Büssgen, Melanie; Schittenhelm, Jens; Salaverria Frigola, Itziar; Campo Güerri, Elias; Coupland, Sarah E.; Quintanilla Martinez, Leticia; Fend, Falko (Data de publicació: 2023-06-16)

Vitreoretinal lymphoma (VRL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL) considered a variant of primary central nervous system lymphoma (PCNSL). Diagnosis of VRL requires examination of vitreous fluid, but ...

Budesonide as first-line treatment in patients with autoimmune hepatitis seems inferior to standard predniso(lo)ne administration 

Díaz González, Álvaro; Hernández Guerra, Manuel; Pérez Medrano, Indhira; Sapena, Víctor; Riveiro-Barciela, Mar; Barreira Díaz, Ana; Gómez, Elena; Morillas, Rosa M.; Barrio, María del; Escudé, Laia; Mateos, Beatriz; Horta, Diana; Gómez, Judith; Conde, Isabel; Ferre Aracil, Carlos; El Hajra, Ismael; Arencibía, Ana; Zamora, Javier; Fernández, Ainhoa; Salcedo, Magdalena; Molina, Esther; Soria, Anna; Estévez, Pamela; López, Carmen; Álvarez Navascúes, Carmen (Data de publicació: 2023-11-17)

In patients with non-severe acute or chronic autoimmune hepatitis (AIH) without cirrhosis, clinical practice guidelines recommend indistinct use of prednisone or budesonide. However, budesonide is infrequently used in ...

The role of specialist nurses in detecting spasticity and related symptoms in multiple sclerosis 

Artola, Montse; Hernando, Ana; Vidal, Núria; Cuenca, Ester; Horno, Rosalía; Robles, Miguel Ángel; Oriol, Clara; Peralta, Sílvia; Solana, José M. A.; Rubio, Matilde; Montero, Cristina; Lleixà, Mercè; Zabay, Cinta; Martin, Montse; Leon, Isabel; Molinos, Consuelo; Matamoros, Mandi; Mercadé, Laura; Fornali, Olga; Montero-Pons, Laura; Saiz, Albert; Solà Valls, Núria (Data de publicació: 2023-11-13)

Spasticity is a frequent symptom of multiple sclerosis (MS), which may negatively influence daily living activities (ADL).To (1) explore the feasibility to conduct a structured interview by specialist nurses about limitations ...

T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and Cancer 

Mazzotti, Lucia; Gaimari, Anna; Bravaccini, Sara; Maltoni, Roberta; Cerchione, Claudio; Juan, Manel; González Navarro, Europa Azucena; Pasetto, Anna; Silva, Daniela Nascimento; Ancarani, Valentina; Sambri, Vittorio; Calabrò, Luana; Martinelli, Giovanni; Mazza, Massimiliano (Data de publicació: 2024-03-27)

The immune system is a dynamic feature of each individual and a footprint of our unique internal and external exposures. Indeed, the type and level of exposure to physical and biological agents shape the development and ...

Linked-color imaging versus high definition white-light endoscopy for evaluation of post-polypectomy scars of nonpedunculated lesions: LCI-Scar study 

Ortiz Zúñiga, Oswaldo; Daca Álvarez, María de los Ángeles; Rivero Sánchez, Liseth; Sáez de Gordoa Elizalde, Karmele; Moreira de Abreu, Rebeca; Cuatrecasas Freixas, Miriam; Balaguer Prunés, Francesc; Pellisé Urquiza, Maria (Data de publicació: 2024-02-26)