Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients 

Rovira Juárez, Jordi; Ramírez Bajo, María José; Bañón Maneus, Elisenda; Hierro García, Natalia; Lazo Rodríguez, Marta; Piñeiro, Gastón Julio; Montagud Marrahi, Enrique; Cucchiari, David; Revuelta, Ignacio; Cuatrecasas Freixas, Miriam; Campistol Plana, Josep M.; Ricart Brulles, Ma. José; Diekmann, Fritz; García Criado, Ángeles; Ventura Aguiar, Pedro (Data de publicació: 2024-01-24)

Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas ...

Emotional intelligence: A comparison between patients after first episode mania and those suffering from chronic bipolar disorder type i 

Varo, Cristina; Amoretti Guadall, Silvia; Sparacino, Giulio; Jiménez Martínez, Ester; Solé Cabezuelo, Brisa; Bonnín Roig, Caterina del Mar; Montejo Egido, Laura; Serra Navarro, Maria; Torrent Font, Carla; Salagre Muñoz, Estela; Benabarre, Antonio; Salgado Pineda, Pilar; Montoro Salvatierra, Irene; Sáiz Martínez, Pilar Alejandra; García Portilla, María Paz; Sánchez Gistau, Vanessa; Pomarol-Clotet, Edith; Ramos Quiroga, Josep Antoni; Pacchiarotti, Isabella; García Rizo, Clemente; Undurraga Fourcade, Juan Pablo; Reinares, María; Martínez-Arán, Anabel, 1971-; Vieta i Pascual, Eduard, 1963-; Verdolini, Norma (Data de publicació: 2024-04-23)

Deficits in emotional intelligence (EI) were detected in patients with Bipolar Disorder (BD), but little is known about whether these deficits are already present in patients after presenting a first episode mania (FEM). ...

Real-life epidemiology and current outcomes of hospitalized adults with invasive fungal infections 

Monzó Gallo, Patricia; Chumbita, Mariana; Lopera, Carlos; Aiello, Tommaso F.; Peyrony, Oliver; Bodro, Marta; Herrera, Sabina; Sempere, Abiu; Fernández Pittol, Mariana; Cuesta, Genoveva; Simó, Sílvia; Benegas, Mariana; Fortuny Guasch, Claudia; Mensa, Josep; Soriano Viladomiu, Alex; Puerta-Alcalde, Pedro; Marco, Francesc; Garcia Vidal, Carolina; FUNGIclinic group (Data de publicació: 2024-01-24)

We aimed to describe the current epidemiology of both hosts with invasive fungal infections (IFI) and causative fungi. And detail outcomes of these infections at 12 weeks in a real-life cohort of hospitalized patients. The ...

Large-scale aggregate data for left bundle branch area pacing as first line for CRT: climbing the pyramid of evidence. 

Pujol López, Margarida; Tung, Rodererick (Data de publicació: 2024-06-10)

Impact of Mesenchymal Stromal Cells and Their Extracellular Vesicles in a Rat Model of Kidney Rejection 

Ramírez Bajo, María José; Rovira Juárez, Jordi; Lazo Rodríguez, Marta; Bañón Maneus, Elisenda; Tubita, Valeria; Moya Rull, Daniel; Hierro García, Natalia; Ventura Abreu Aguiarà, Pedro; Oppenheimer Salinas, Federico; Campistol Plana, Josep M.; Diekmann, Fritz (Data de publicació: 2025-11-14)

Background: Mesenchymal stromal cells (MSCs) from different sources possess great therapeutic potential due to their immunomodulatory properties associated with allograft tolerance. However, a crucial role in this activity ...

Streptococcus pneumoniae-associated pneumonia complicated by purulent pericarditis: case series 

Cillóniz, Catia; Rangel, Ernesto; Barlascini, Cornelius; Piroddi, Ines Maria Grazia; Torres Martí, Antoni; Nicolini, Antonello (Data de publicació: 2019-11-25)

Objective: In the antibiotic era, purulent pericarditis is a rare entity. However, there are still reports of cases of the disease, which is associated with high mortality, and most such cases are attributed to delayed ...

Effect of moderate beer consumption (with and without ethanol) on osteoporosis in early postmenopausal women: Results of a pilot parallel clinical trial 

Trius-Soler, Marta; Tresserra i Rimbau, Anna; Moreno, Juan J.; Peris Bernal, Pilar; Estruch Riba, Ramon; Lamuela Raventós, Rosa Ma. (Data de publicació: 2024-01-24)

Osteoporosis is a chronic progressive bone disease characterized by low bone mineral density (BMD) and micro-architectural deterioration of bone tissue, leading to an increase in bone fragility and the risk of fractures. ...

Paradoxical suboptimal vitamin D levels in a Mediterranean area: a population-based study 

Díaz Rizzolo, D. A.; Kostov, Benchi; Gomis i Cabré, Roger; Sisó Almirall, Antoni (Data de publicació: 2023-08-02)

Policies in sunny countries, such as those in the Mediterranean area, do not promote vitamin D supplementation despite some studies might suggest the high prevalence of sub-optimal levels. The objective was to determine ...

Polymicrobial community-acquired pneumonia requiring mechanical ventilation: A case series 

Piroddi, Ines Maria Grazia; Cillóniz, Catia; Flores, Karina; Antonello, Nicolini (Data de publicació: 2019-11-25)

Polymicrobial pneumonia may cause by combinations of respiratory viruses and bacteria in a host. Colonization by Streptococcus pneumoniae was associated with increased risk of Intensive Care Unit admission or death in ...

Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation 

Seron, Daniel; Rabant, Marion; Becker, Jan Ulrich; Roufosse, Candice; Bellini, Maria Irene; Böhmig, Georg A.; Budde, Klemens; Diekmann, Fritz; Glotz, Denis; Hilbrands, Luuk; Loupy, Alexandre; Oberbauer, Rainer; Pengel, Liset; Schneeberger, Stefan; Naesens, Maarten (Data de publicació: 2024-01-24)

The diagnosis of acute T cell-mediated rejection (aTCMR) after kidney transplantation has considerable relevance for research purposes. Its definition is primarily based on tubulointerstitial inflammation and has changed ...

Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study 

Ende, Emma L. van der; Heller, Carolin; Sogorb Esteve, Aitana; Swift, Imogen J.; McFall, David; Peakman, Georgia; Bouzigues, Arabella; Poos, Jackie M.; Jiskoot, Lize C.; Panman, Jessica L.; Papma, Janne M.; Meeter, Lieke H.; Dopper, Elise G. P.; Bocchetta, Martina; Todd, Emily; Cash, David; Graff, Caroline; Synofzik, Matthis; Moreno, Fermin; Finger, Elizabeth; Sánchez Valle, Raquel; Vandenberghe, Rik; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B.; Butler, Chris; Ducharme, Simon; Gerhard, Alexander; Danek, Adrian; Levin, Johannes; Pijnenburg, Yolande A. L.; Otto, Markus; Borroni, Barbara; Tagliavini, Fabrizio; Mendonça, Alexandre de; Santana, Isabel; Galimberti, Daniela; Sorbi, Sandro; Zetterberg, Henrik (Data de publicació: 2024-01-30)

Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate ...

Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects 

Rami González, Lorena; León, María; Valech, Natalia; Coll Padrós, Nina; Bosch, Beatriz; Olives, Jaume; Salinero, Ana; Pérez Millan, Agnès; Molinuevo, José Luis; Sánchez Valle, Raquel; Tort Merino, Adrià (Data de publicació: 2024-01-23)

Subtle decline in memory is thought to arise in the preclinical phase of Alzheimer's disease (AD). However, detecting these initial cognitive difficulties cross-sectionally has been challenging, and the exact nature of the ...

Satisfaction and effectiveness of switching from intravenous to subcutaneous belimumab treatment in daily clinical practice 

Frade Sosa, Beatriz; Salman Monte, Tarek Carlos; Narváez García, Francisco Javier; Peralta, Irene; Sandoval, Sebastian; Magallares, Berta; Heredia, Sergi; Sapena, Nuria; Riveros Frutos, Anne; Olive, Alejandro; Corominas, Hector; Cortes Hernandez, Josefina; Gómez-Puerta, José Alfredo (Data de publicació: 2024-12-02)

Background In 2017, belimumab (BEL) was approved in subcutaneous (SQ) administration. The effectiveness after switching from intravenous (IV) to SQ and patient satisfaction in daily clinical practice has not been studied. ...

Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome 

Hong, Chung Hwan; Ko, Myoung Seok; Kim, Jae Hyun; Cho, Hyunkyung; Lee, Chi-Ho; Yoon, Ji Eun; Yun, Ji-Young; Baek, In-Jeoung; Jang, Jung Eun; Lee, Seung Eun; Cho, Yun Kyung; Baek, Ji Yeon; Oh, Soo Jin; Lee, Bong Yong; Lim, Joon Seo; Lee, Jongkook; Hartig, Sean M.; Conde de la Rosa, Laura; García Ruiz, Carmen; Lee, Ki-Up; Fernández Checa Torres, José Carlos; Choi, Ji Woong; Kim, Sanghee; Koh, Eun Hee (Data de publicació: 2023-06-21)

BACKGROUND & AIMS: Sphingosine 1-phosphate receptors (S1PRs) are a group of G-protein-coupled receptors that confer a broad range of functional effects in chronic inflammatory and metabolic diseases. S1PRs also may mediate ...

An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions 

Chua, Winnie; Cardoso, Victor R.; Guasch i Casany, Eduard; Sinner, Moritz F.; Al Taie, Christoph; Brady, Paul; Casadei, Barbara; Crijns, Harry J. G. M.; Dudink, Elton A. M. P.; Hatem, Stéphane N.; Kaab, Stefan; Kastner, Peter; Mont Girbau, Lluís; Nehaj, Frantisek; Purmah, Yanish; Reyat, Jasmeet S.; Schotten, Ulrich; Sommerfeld, Laura C.; Zeemering, Stef; Ziegler, André; Gkoutos, Georgios V.; Kirchhof, Paulus; Fabritz, Larissa (Data de publicació: 2024-01-23)

Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a cross-sectional, observational study, we ...

Factors affecting engagement of primary health care professionals and their patients in facilitated access to online alcohol screening and brief intervention 

López Pelayo, Hugo; Wallace, Paul; Miquel de Montagut, Laia; Segura García, Lidia; Baena, Begoña; Barrio, Pablo; Colom, Joan; Gual, Antoni; EFAR group (Data de publicació: 2020-03-09)

Objective: Understanding the impact of Level of Information and Communication Technology Use, computer self-efficacy and perceived product usability of healthcare professionals regarding an alcohol consumption reduction ...

Microbiological testing of adults hospitalised with community-acquired pneumonia: an international study 

Carugati, Manuela; Aliberti, Stefano; Reyes, Luis F.; Franco Sadud, Ricardo; Irfan, Muhammad; Prat, Cristina; Soni, Nilam J.; Faverio, Paola; Gori, Andrea; Blasi, Francesco; Restrepo, Marcos I.; Cillóniz, Catia; Torres Martí, Antoni; GLIMP collaborators (Data de publicació: 2019-07-09)

This study aimed to describe real-life microbiological testing of adults hospitalised with community-acquired pneumonia (CAP) and to assess concordance with the 2007 Infectious Diseases Society of America (IDSA)/American ...

A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma 

Encinas, Cristina; Hernández Rivas, José Ángel; Oriol, Albert; Rosiñol Dachs, Laura; Blanchard, María Jesús; Bellon, José María; Garcia Sanz, Ramón; Rubia, Javier de la; López Guía, Ana de la; Jiménez Ubieto, Ana; Jarque, Isidro; Iñigo, Belén; Dourdil, Victoria; Arriba, Felipe de; Cuéllar Pérez-Ávila, Clara; González, Yolanda; Hernández, Miguel Teodoro; Bargay, Joan; Granell, Miguel; Rodríguez Otero, Paula; Silvent, Maialen; Cabrera, Carmen; Rios, Rafael; Alegre, Adrián; Gironella, M.; González, M. S.; Sureda, Anna; Sampol, A.; Ocio, Enrique M.; Krsnik, I.; Garcia, A.; García Mateo, A.; Soler, J. A.; Martin, J.; Arguiñano, J. M.; Mateos, M. V.; Bladé, J. (Joan); San Miguel, J. F.; Lahuerta, J. J.; Martínez López, Joaquín; GEM/PETHEMA (Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Group (Data de publicació: 2024-02-16)

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER⁺ breast cancer 

Palafox Sánchez, Marta; Monserrat Vicente, Laia; Bellet Ezquerra, Meritxell; Villacampa, Guillermo; González Pérez, Abel; Oliveira, Mafalda; Brasó Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera Abreu, Maria Teresa; Odena, Andreu; Sánchez Guixé, Mònica; Capelán, Marta; Azaro, Analía; Bruna, Alejandra; Rodriguez, Olga; Guzmán, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert; Caldas, Carlos; Arribas, Joaquín; Michiels, Stefan; García Sanz, Alicia; Turner, Nicholas, 1951-; Prat Aparicio, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S; López Bigas, Núria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra Elizalde, Violeta (Data de publicació: 2023-04-27)

CDK4/6 inhibitors combined with endocrine therapy have demonstrated higher antitumor activity than endocrine therapy alone for the treatment of advanced estrogen receptor-positive breast cancer. Some of these tumors are ...

Prevalence, features and predictive factors of liver nodules in Fontan surgery patients: The VALDIG Fonliver prospective cohort 

Téllez, Luis; Rodríguez de Santiago, Enrique; Minguez, Beatriz; Payancé, Audrey; Clemente, Ana; Baiges i Jardí, Anna; Morales Arraez, Dalia; Mura, Vincenzo La; Llop, Elba; Garrido, Elena; Garrido Lestache, Elvira; Tasayco, Stephanie; Bruno, Onorina; Prieto, Raquel; Montserrat-Vila, Sílvia; Pons, Mónica; Olavarría, Andreína; Dos, Laura; Legendre, Antoine; Cerro, María Jesús del; Rodríguez de Santiago, Enrique; Bañares, Rafael; García Pagán, Juan Carlos; Rautou, Pierre-Emmanuel; Albillos, Agustín; VALDIG an EASL consortium (Data de publicació: 2020-05-14)

Background & Aims: Fontan surgery is used to treat a variety of congenital heart malformations, and may lead to advanced chronic liver disease in the long-term. This study examines the prevalence, characteristics and ...