Fonaments Clínics: Recent submissions
Now showing items 361-380 of 627
Quantitative comparison of DNA methylation assays for biomarker development and clinical applications
DNA methylation patterns are altered in numerous diseases and often correlate with clinically relevant information such as disease subtypes, prognosis and drug response. With suitable assays and after validation in large ...
Efectos de una dieta hiperlipídica sobre la carcinogénesis mamaria experimental: contenido y tipo de tumores
En el presente trabajo se han estudiado los efectos de una dieta hiperlipídica (20 % aceite de maíz) sobre las principales etapas de la carcinogénesis. Dicho estudio se ha realizado utilizando como soporte experimental el ...
MRI at 12 ± 2 months' corrected age without sedation
(Letter to the Editor) Sir, We read with interest the article by Edwards and Arthurs [1] about the methodological challenges of acquiring highquality MRI in young children. Although the use of anaesthesia and sedation is ...
MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells
MicroRNAs are critical regulators of gene networks in normal and abnormal biological processes. Focusing on invasive ductal breast cancer (IDC), we have found dysregulated expression in tumor samples of several microRNAs, ...
Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion ...
Controlling Antibacterial Activity Exclusively with Visible Light: Introducing a Tetra-ortho-Chloro-Azobenzene Amino Acid
The introduction of a novel tetra-ortho-chloroazobenzene amino acid (CEBA) has enabled photoswitching of the antimicrobial activity of tyrocidine A analogues by using exclusively visible light, granting spatiotemporal ...
L’aprenentatge basat en la indagació i el codisseny. Experiència aplicada al Grau d’Enginyeria Biomèdica
Podeu consultar la versió castellana al camp recurs relacionat.
IGLV3-21R110 mutation has prognostic value in patients with treatment-naive chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) has high biological and clinical heterogeneity. 1,2 A few prognostic factors are used in clinical practice, including immunoglobulin heavy-chain variable (IGHV) gene somatic hypermutation ...
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target
Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we ...
Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD
Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely ...
Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia.
Gene expression profiling studies could be a valuable tool in identifying the specific genes and pathways involved in the mechanism of action of clozapine, leading to a better understanding of the molecular biology underlying ...
Academic challenges on advanced therapy medicinal products’ development: a regulatory perspective
Advanced therapy medicinal products (ATMPs) are becoming the new kid on the block for the treatment of a variety of indications with promising results. Despite the academic contribution to the basic and clinical research ...
OntoCR: A CEN/ISO-13606 clinical repository based on ontologies
Objective: To design a new semantically interoperable clinical repository, based on ontologies, conforming to CEN/ISO 13606 standard. Materials and Methods: The approach followed is to extend OntoCRF, a framework for the ...
Effects of the COVID-19 pandemic and lockdown in Spain: comparison between community controls and patients with a psychiatric disorder. Preliminary results from the BRIS-MHC STUDY
Background: The aim of this study was to evaluate potential differences about the effects of the COVID-19 pandemic and lockdown between community controls (CC) and patients with a mental illness (MI) in a Spanish population ...
Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis.
OBJECTIVE: Uncontrolled studies of mesenchymal stem cells (MSCs) in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind, placebo-controlled, crossover phase II study we investigated their ...
The DNA methylation drift of the atherosclerotic aorta increases with lesion progression
Background: Atherosclerosis severity-independent alterations in DNA methylation, a reversible and highly regulated DNA modification, have been detected in aortic atheromas, thus supporting the hypothesis that epigenetic ...
Gene expression imputation provides clinical and biological insights into treatment-resistant schizophrenia polygenic risk
Genome-wide association studies (GWAS) have revealed the polygenic nature of treatment-resistant schizophrenia TRS. Gene expression imputation allowed the translation of GWAS results into regulatory mechanisms and the ...
Reliable identification of women with CIN3+ using hrHPV genotyping and methylation markers in a cytology-screened referral population.
Cervical screening aims to identify women with high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 2-3 (HSIL/CIN2-3) or invasive cervical cancer (ICC). Identification of women with severe premalignant ...
Cáncer de mama localmente avanzado: revisión bibliográfica y resultados en una serie de 164 casos
Introducción: el estadio III del cáncer de mama comprende 2 entidades de incidencia, pronóstico, evolución clínica y terapéutica diferentes; se trata del cáncer de mama localmente avanzado propiamente dicho y del carcinoma ...
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism; intervention; and long-term consequences.
Background Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously ...
