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Fonaments Clínics: Envíos recientes

Mostrando ítems 181-200 de 627

    Detection of human cytomegalovirus in bronchoalveolar lavage of intensive care unit patients 

    Vergara, Andrea; Cillóniz, Catia; Luque Chipana, Néstor Alejandro; Garcia Vidal, Carolina; Tejero Salvador, Xavier; Perelló, Rafael; Lucena, Carmen M.; Torres Martí, Antoni; Marcos, Ma. Angeles (Fecha de publicación: 2019-11-12)

    The seroprevalence of human cytomegalovirus (CMV) is very high worldwide [1, 2] and the spectrum of disease caused by it ranges from an asymptomatic state to a mononucleosis-like syndrome to severe diseases such as pneumonia, ...

    Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics. 

    Speedy, Helen E.; Beekman, Renée; Chapaprieta, Vicente; Orlando, Giulia; Law, Philip J.; Martín García, David; Gutiérrez-Abril, Jesús; Catovsky, Daniel; Beà Bobet, Sílvia M.; Clot Razquin, Guillem; Puiggròs, Montserrat; Torrents Arenales, David; Puente, Xose S.; Allan, James M.; López-Otin, Carlos; Campo Güerri, Elias; Houlston, Richard S.; Martín-Subero, José Ignacio (Fecha de publicación: 2020-01-16)

    Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin accessibility, ...

    The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy. 

    Santacruz, Rodrigo; Villamor i Casas, Neus; Aymerich Gregorio, Marta; Martínez Trillos, Alejandra; López González, Cristina; Navarro López, Alba; Rozman, María; Beà Bobet, Sílvia M.; Royo Moreno, Cristina; Cazorla, Maite; Colomer Pujol, Dolors; Giné Soca, Eva; Pinyol, Magda; Puente, Xose S.; López-Otin, Carlos; Campo Güerri, Elias; López Guillermo, Armando; Delgado, Julio (Delgado González) (Fecha de publicación: 2018-03-27)

    A proportion of patients with chronic lymphocytic leukemia achieve a minimal residual disease negative status after therapy. We retrospectively evaluated the impact of minimal residual disease on the outcome of 255 consecutive ...

    Combining OPM and lesion mapping data for epilepsy surgery planning: a simulation study 

    The MELD Project Consortium; Bargalló Alabart, Núria; Pascual-Diaz, Saül; González Ortiz, Sofía; Conde Blanco, Estefanía; Pariente, Jose Carlos (Fecha de publicación: 2025-06-12)

    When planning for epilepsy surgery, multiple potential sites for resection may be identified through anatomical imaging. Magnetoencephalography (MEG) using optically pumped sensors (OP-MEG) is a non-invasive functional ...

    Effects of the COVID-19 pandemic and lockdown in Spain: comparison between community controls and patients with a psychiatric disorder. Preliminary results from the BRIS-MHC STUDY 

    Solé Cabezuelo, Brisa; Verdolini, Norma; Amoretti Guadall, Silvia; Montejo Egido, Laura; Rosa, Adriane Ribeiro; Hogg, Bridget; García Rizo, Clemente; Mezquida Mateos, Gisela; Bernardo Arroyo, Miquel; Martínez-Arán, Anabel, 1971-; Vieta i Pascual, Eduard, 1963-; Torrent Font, Carla (Fecha de publicación: 2026-01-19)

    Background: The aim of this study was to evaluate potential differences about the effects of the COVID-19 pandemic and lockdown between community controls (CC) and patients with a mental illness (MI) in a Spanish population ...

    Evaluation of a Mixing versus a Cycling Strategy of Antibiotic Use in Critically-Ill Medical Patients: Impact on Acquisition of Resistant Microorganisms and Clinical Outcomes 

    Cobos-Trigueros, Nazaret; Solé, Mar; Castro, Pedro; Torres, Jorge Luis; Rinaudo, Mariano; Lazzari, Elisa de; Morata, Laura; Hernández-Munain, Cristina; Fernández, Sara (Fernández García); Soriano Viladomiu, Alex; Nicolás Arfelis, Josep Maria; Mensa Pueyo, Josep; Vila Estapé, Jordi; Martínez, José Antonio (Martínez Martínez) (Fecha de publicación: 2016-05-19)

    OBJECTIVE: To compare the effect of two strategies of antibiotic use (mixing vs. cycling) on the acquisition of resistant microorganisms, infections and other clinical outcomes. METHODS: ...

    Response to fluoxetine in children and adolescents: a weighted gene co-expression network analysis of peripheral blood 

    Torres, Teresa; Boloc, Daniel; Rodríguez Ferret, Natalia; Blázquez, Ana; Plana, Maria Teresa; Varela, Eva; Gassó Astorga, Patricia; Martínez Pinteño, Albert; Lázaro García, Luisa; Arnaiz Gargallo, Juan Alberto; Mas Herrero, Sergi (Fecha de publicación: 2021-03-08)

    The inconclusive and non-replicated results of pharmacogenetic studies of antidepressant response could be related to the lack of acknowledgement of its mechanism of action. In this scenario, gene expression studies provide ...

    Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis. 

    Llufriu Duran, Sara; Sepúlveda, María; Blanco, Yolanda; Marín, Pedro; Moreno, Beatriz; Berenguer, Joan; Gabilondo, Iñigo; Martinez-Heras, Eloy; Sola Valls, Nuria; Arnaiz Gargallo, Juan Alberto; Andreu, Enrique J.; Fernández, Begoña; Bullich Roig, Santiago; Sánchez Dalmau, Bernardo; Graus Ribas, Francesc; Villoslada, Pablo; Saiz Hinarejos, Albert (Fecha de publicación: 2018-01-31)

    OBJECTIVE: Uncontrolled studies of mesenchymal stem cells (MSCs) in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind, placebo-controlled, crossover phase II study we investigated their ...

    Spontaneous abortion associated with Zika virus infection and persistent viremia 

    Goncé Mellgren, Anna; Martínez Yoldi, Miguel Julián; Marbán Castro, Elena; Saco, Adela; Soler, Anna; Álvarez Mora, María Isabel; Peiró Mestres, Aida; Gonzalo, Verónica; Hale, Gillian; Bhatnagar, Julu; López, Marta; Zaki, Sherif R.; Ordi i Majà, Jaume; Bardají, Azucena (Fecha de publicación: 2019-06-05)

    We report a case of spontaneous abortion associated with Zika virus infection in a pregnant woman who traveled from Spain to the Dominican Republic and developed a rash. Maternal Zika ...

    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia 

    Berndt, Sonja I.; Skibola, Christine F.; Joseph, Vijai; Camp, Nicola J.; Nieters, Alexandra; Wang, Zhaoming; Cozen, Wendy; Monnereau, Alain; Wang, Sophia S.; Kelly, Rachel S.; Lan, Qing; Teras, Lauren R.; Chatterjee, Nilanjan; Chung, Charles C.; Yeager, Meredith; Brooks-Wilson, Angela R.; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda M.; Armstrong, Bruce K.; Cocco, Pierluigi; Zhang, Yawei; Severi, Gianluca; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Burdette, Laurie; Yuenger, Jeffrey; Hutchinson, Amy; Jacobs, Kevin B.; Call, Timothy G.; Shanafelt, Tait D.; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Wang, Alice H.; Smedby, Karin E.; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A.; Jones, Brandt; Diver, W. Ryan; Link, Brian K.; Weiner, George J.; Conde, Lucía; Bracci, Paige M.; Riby, Jacques; Holly, Elizabeth A.; Smith, Martyn T.; Jackson, Rebecca D. J.; Tinker, Lesley F.; Benavente, Yolanda; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadié, Marc; McKay, James D.; Staines, Anthony (Fecha de publicación: 2018-11-12)

    Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted ...

    Biological prognostic and therapeutic impact of the epigenome in CLL 

    Maiques Diaz , Alba; Martín-Subero, José Ignacio (Fecha de publicación: 2024-11-18)

    Chronic lymphocytic leukemia (CLL) is characterized by widespread alterations in the genetic and epigenetic landscapes which seem to underlie the variable clinical manifestations observed in patients. Over the last decade, ...

    A comparison of RNA-Seq results from paired formalin-fixed paraffin-embedded and fresh-frozen glioblastoma tissue samples. 

    Esteve Codina, Anna; Arpi, Oriol; Martínez-García, María; Pineda, Estela; Mallo, Mar; Gut, Marta; Carrato, Cristina; Rovira, Anna; López, Raquel; Tortosa i Moreno, Avelina; Dabad, Marc; Barco, Sonia del; Heath, Simon C.; Bagué, Silvia; Ribalta Farrés, Teresa María; Alameda, Francesc; Iglesia, Núria de la; Balaña, Carmen; GLIOCAT Group (Fecha de publicación: 2017-03-20)

    The molecular classification of glioblastoma (GBM) based on gene expression might better explain outcome and response to treatment than clinical factors. Whole transcriptome sequencing using next-generation sequencing ...

    Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity 

    Guo, Yan; Lu, Xiaoqin; Chen, Yao; Clark, Geoff; Trent, John; Cuatrecasas Freixas, Miriam; Emery, Douglas; Song, Zhao-Hui; Chariker, Julia; Rouchka, Eric; Postigo, Antonio; Liu, Yongqing; Dean, Douglas C. (Fecha de publicación: 2023-08-30)

    Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and is initiated by mesenchyme-driving transcription factors and actin cytoskeletal assembly. We show a cytoplasmic-to-nuclear transport gradient of the ...

    Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction 

    Aguiar, Pablo; Pino Sorroche, Francisco; Silva-Rodríguez, Jesús; Pavía Segura, Javier; Ros Puig, Domènec; Ruibal Morell, Álvaro; El Bitar, Ziad (Fecha de publicación: 2017-06-28)

    PURPOSE: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. METHODS: Evaluation was performed using ...

    Oncological Results of Laparoscopically Assisted Radical Vaginal Hysterectomy. Should we really abandon minimal invasive surgeryin early-stage cervical cancer? 

    Torné Bladé, Aureli; Pahisa Fábregas, Jaume; Ordi i Majà, Jaume; Fusté, Pere; Martí; Díaz Feijoo, Berta; Paredes Barranco, Pilar; Rovirosa Casino, Angeles; Gaba, Lydia; Saco, Adela; Nicolau, Carlos; Carreras-Dieguez, Nuria; Agustí, Núria; Vidal i Sicart, Sergi; Gil Ibáñez, Blanca; Glickman, Ariel; Pino Saladrigues, Marta del (Fecha de publicación: 2021-11-09)

    Background: Recent evidence indicates that some minimally invasive surgery approaches, such as laparoscopic and robotic-assisted radical hysterectomy, offer lower survival rates to patients with early-stage cervical cancer ...

    Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma. 

    Rakislova, Natalia; Montironi, Carla; Aldecoa Ansórregui, Iban; Fernandez, Eva; Bombí, Josep Antoni; Jimeno, Mireya; Balaguer Prunés, Francesc; Pellisé Urquiza, Maria; Castells Garangou, Antoni; Cuatrecasas Freixas, Miriam (Fecha de publicación: 2017-04-11)

    Background Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and extensive ...

    Complete response under sorafenib in patients with hepatocellular carcinoma: Relationship with dermatologic adverse events. 

    Rimola Gibert, Jordi; Díaz González, Álvaro; Reig, María; Darnell, Anna; Varela, María; Pons, Fernando; Hernández Guerra, Manuel; Delgado, Manuel; Castroagudin, Javier; Matilla, Ana; Sangro, Bruno; Rodriguez de Lope, Carlos; Sala, Margarita; Gonzalez, Carmen; Huertas, Carlos; Minguez, Beatriz; Ayuso Colella, Carmen; Bruix Tudó, Jordi (Fecha de publicación: 2018-02-21)

    The clinical benefit of sorafenib in patients with hepatocellular carcinoma (HCC) has been undervalued due to the absence of complete responses, even though patients who develop early dermatologic reactions have shown to ...

    Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma 

    Recasens Zorzo, Clara; Cardesa Salzmann, Teresa; Petazzi, Paolo; Ros Blanco, Laia; Esteve Arenys, Anna; Clot Razquin, Guillem; Guerrero Hernández, Martina; Rodríguez, Vanina; Soldini, Davide; Valera Barros, Alexandra; Moros Sanz, Alexandra; Climent, Fina; González Barca, Eva; Mercadal, Santiago; Arenillas Rocha, Leonor; Calvo, Xavier; Mate, José L.; Gutiérrez García, Gonzalo; Casanova Rigat, Isolda; Mangues Bafalluy, Ramon; Sanjuan Pla, Alejandra; Bueno, Clara; Menéndez Buján, Pablo; Martínez, Antonio; Colomer Pujol, Dolors; Estrada Tejedor, Roger; Teixidó, Jordi; Campo Güerri, Elias; López Guillermo, Armando; Borrell, José Ignacio; Colomo Saperas, Lluís; Pérez Galán, Patricia; Roué, Gaël (Fecha de publicación: 2020-01-15)

    Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested ...

    Outcomes of corticosteroid therapy in patients with viral community-acquired pneumonia 

    Cillóniz, Catia; Guzzardella, Amedeo; Calabretta, David; Gabarrús Barri, Albert; Marcos, María Ángeles; Torres Martí, Antoni (Fecha de publicación: 2025-04-30)

    Aim: The objective of this study was to assess the therapeutic effects of corticosteroids in adult patients hospitalized with viral community-acquired pneumonia. Methods: This is a retrospective analysis of data collected ...

    Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia 

    Olivares Berjaga, David; Martínez Pinteño, Albert; Rodríguez Ferret, Natalia; Madero Gómez, Santiago; Prohens Coll, Llucia; Mas Herrero, Sergi; Morén Núñez, Constanza; Parellada Rodón, Eduard; Gassó Astorga, Patricia; Martínez Serrano, Irene (Fecha de publicación: 2025-02-25)

    Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating the negative and cognitive symptoms. The SZ glutamatergic dysfunction hypothesis has opened new avenues in the ...