Fonaments Clínics: Envíos recientes
Mostrando ítems 41-60 de 627
Pathological Methods Applied to the Investigation of Causes of Death in Developing Countries: Minimally Invasive Autopsy Approach
BACKGROUND AND AIMS: Complete diagnostic autopsies (CDA) remain the gold standard in the determination of cause of death (CoD). However, performing CDAs in developing countries is challenging due to limited facilities and ...
Specialist laboratory networks as preparedness and response tool - the Emerging Viral Diseases-Expert Laboratory Network and the Chikungunya outbreak, Thailand, 2019.
We illustrate the potential for specialist laboratory networks to be used as preparedness and response tool through rapid collection and sharing of data. Here, the Emerging Viral Diseases-Expert Laboratory Network (EVD-LabNet) ...
A practical guide for mutational signature analysis in hematological malignancies
Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and ...
Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort
Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic ...
Methodological quality and reporting of Generalized Linear Mixed Models in clinical medicine (20002012): a systematic review
Background: Modeling count and binary data collected in hierarchical designs have increased the use of Generalized Linear Mixed Models (GLMMs) in medicine. This article presents a systematic review of the application and ...
Protease inhibitor monotherapy is associated with a higher level of monocyte activation, bacterial translocation and inflammation
Introduction Monotherapy with protease-inhibitors (MPI) may be an alternative to cART for HIV treatment. We assessed the impact of this strategy on immune activation, bacterial translocation and inflammation. Methods We ...
High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection
BACKGROUND: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses ...
Neurobehavioral conditions and effects of gender, weight and severity in preterm infants according to the Neonatal Behavioral Assessment Scale
Abstract: The increasing number of preterm babies in recent years has raised interest in studying the consequences of prematurity as a risk factor. In the present paper, 30 preterm babies (at 40 weeks of gestational age) ...
A comparative study between real-time PCR and loop-mediated isothermal amplification to detect carbapenemase and/or ESBL genes in Enterobacteriaceae directly from bronchoalveolar lavage fluid samples
Objectives: To evaluate and compare the efficacy of real-time PCR (Xpert Carba-R) and loop-mediated isothermal amplification (Eazyplex® SuperBug CRE) for detecting carbapenemase carriage in Enterobacteriaceae directly from ...
Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii
The treatment of some infectious diseases can currently be very challenging since the spread of multi-, extended- or pan-resistant bacteria has considerably increased over time. On ...
SiNoPsis: single nucleotide polymorphisms selection and promoter profiling
Motivation: The selection of a single nucleotide polymorphism (SNP) using bibliographic methods can be a very time-consuming task. Moreover, a SNP selected in this way may not be easily visualized in its genomic context ...
Experiencia con la dieta cetogénica como tratamiento en la epilepsia refractaria
Introducción: La epilepsia es una enfermedad neurológica que se controla con fármacos antiepilépticos en la mayoría de casos. Sin embargo, aproximadamente un 25% de epilepsias son refractarias al tratamiento farmacológico. ...
Postoperatorio del paciente pediátrico trasplantado renal
El trasplante renal es la modalidad de tratamiento sustitutivo que mejores resultados proporciona a niños afectos de insuficiencia renal crónica terminal, aunque no está exenta de una importante morbilidad y mortalidad. ...
Development of a post-mortem procedure to reduce the uncertainty regarding causes of death in developing countries
A major failure of our global society in the 21st century is that many people in developing countries are not only born and live without any official record of their existence a flagrant deprivation of an essential human ...
Tromboflebitis profundas en la edad infantil
Se recogen cinco casos de variada etiolog{a (osteomielitis del ilíaco, coma diabético hiperosmolar, sepsis meningocócica con shock y C.I.D., traumatismo de cadera y cateterización de vena femoral) que cursaron con ...
Impact of a systematic evaluation of connective tissue disease on diagnosis approach in patients with interstitial lung diseases
To date, there is no clear agreement regarding which is the best method to detect a connective tissue disease (CTD) during the initial diagnosis of interstitial lung diseases (ILD). The aim of our study was to explore the ...
Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipshycotics
In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by ...
Seminaris pràctics mitjançant l'aprenentatge basat en problemes en l'ensenyament de la pediatria
Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352
Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women
BACKGROUND: Plasmodium falciparum in pregnancy results in substantial poor health outcomes for both mother and child, particularly in young, primigravid mothers who are at greatest ...
Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis
Background Herpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to assess the frequency, symptoms, risk factors, and outcomes of this complication. Methods We did ...
