Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/156048

Título:	Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipshycotics
Autor/a:	Boloc, Daniel; Gortat, Anna; Cheng-Zhang, Jia Qi; García-Cerro, Susana; Rodríguez Ferret, Natalia; Parellada, Mara; Saiz Ruiz, Jerónimo; Cuesta, Manuel J.; Gassó Astorga, Patricia; Lafuente, Amàlia, 1952-; Bernardo Arroyo, Miquel; Mas Herrero, Sergi
Notas:	In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by increasing its biological plausibility and replication. We re-sequence the four genes using next-generation sequencing. We predict functionality 'in silico' of all identified SNPs and test it using gene reporter assays. Using functional SNPs, we develop a new predictor utilizing machine learning algorithms (Discovery Cohort, N = 131) and replicate it in two independent cohorts (Replication Cohort 1, N = 113; Replication Cohort 2, N = 113). After prioritization, four SNPs were used to develop the pharmacogenetic predictor of AP-induced EPS. The model constructed using the Naive Bayes algorithm achieved a 66% of accuracy in the Discovery Cohort, and similar performances in the replication cohorts. The result is an improved pharmacogenetic predictor of AP-induced EPS, which is more robust and generalizable than the original.
Materia(s):	-Farmacogenètica -Antipsicòtics -Pharmacogenetics -Antipsychotic drugs
Derechos:	cc-by-nc-nd (c) Boloc, Daniel et al., 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Nature Publishing Group
Compartir:

Mostrar el registro completo del ítem