Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry 

Conde, Esther; Suárez Gauthier, Ana; Benito, Amparo; Garrido, Pilar; García Campelo, Rosario; Biscuola, Michele; Paz-Ares, Luis; Hardisson, David; Castro, Javier de; Camacho, María del Carmen; Rodríguez Abreu, Delvys; Abdulkader, Ihab; Ramírez Ruz, J. (José); Reguart, Noemí; Salido Galeote, Marta; Pijuan, Lara; Arriola Aperribay, Edurne; Sanz, Julián; Folgueras, Victoria; Villanueva, Noemí; Gómez Román, Javier; Hidalgo, Manuel; López Ríos, Fernando (Fecha de publicación: 2017-12-15)

Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been greater. However, there are increasing number of recent ...

Humans shape the year-round distribution and habitat use of an opportunistic scavenger 

Ramírez Benítez, Francisco José; Afan, Isabel; Bouten, Willem; Carrasco Jordan, Josep Lluís; González Forero, Manuela; Navarro, Joan (Fecha de publicación: 2021-07-28)

Research focused on evaluating how human food subsidies influence the foraging ecology of scavenger species is scarce but essential for elucidating their role in shaping behavioral patterns, population dynamics, and potential ...

Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity 

Gassó Astorga, Patricia; Ritter, Marie A.; Mas Herrero, Sergi; Lafuente, Amàlia, 1952-2022 (Fecha de publicación: 2017-03-29)

ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO ...

Reversal of rivaroxaban-induced alterations on hemostasis by different coagulation factor concentrates - In vitro studies with steady and circulating human blood - 

Escolar Albaladejo, Ginés; Arellano Rodrigo, Eduardo; López Vilchez, Irene; Molina, Patricia; Sanchis Forés, Juan; Reverter Calatayud, Juan Carlos; Carné Cladellas, Xavier; Cid Vidal, Joan; Villalta i Blanch, Jaume; Tàssies Penella, María Dolores; Galan, Ana M.; Diaz Ricart, M. Isabel (Fecha de publicación: 2017-07-18)

BACKGROUND: Despite the good safety of rivaroxaban, there is limited information on strategies for urgent reversal of its antihemostatic effects.Methods and Results:Alterations of hemostasis induced by rivaroxaban (230 ...

Nasopharyngeal bacterial load as a marker for rapid and easy diagnosis of invasive pneumococcal disease in children from Mozambique 

Brotons, Pedro; Bassat Orellana, Quique; Lanaspa, Miguel; Henares, Desiree; Perez-Arguello, Amaresh; Madrid, Lola; Balcells, Reyes; Acácio, Sozinho; Andres-Franch, Maria; Marcos, Ma. Angeles; Valero-Rello, Ana; Muñoz-Almagro, Carmen (Fecha de publicación: 2017-10-20)

Background Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience. This study aimed ...

Síndrome Hemolítico Urémico 

Palomeque, A.; Pastor Durán, Xavier; Muro, D. (Fecha de publicación: 2014-12-02)

INTRODUCCIÓN Esta entidad (SHU) fue descrita por Gasser (1) en 1955; desde entonces se ha progresado ensu epidemiología y patología, algo en su etiología y siguen existiendo dudas sobre su patogenia. El progreso en su ...

Analysis of Systemic Inflammatory Factors and Survival Outcomes in Endometrial Cancer Patients Staged I-III FIGO and treated with Postoperative External Radiotherapy 

Holub, Katarzyna; Busato, Fabio; Gouy, Sebastien; Sun, Roger; Pautier, Patricia; Genestie, Catherine; Morice, Philippe; Leary, Alexandra; Deutsch, Eric; Haie-Meder, Christine; Biete Solà, Albert; Chargary, Cyrus (Fecha de publicación: 2021-03-10)

Background: The causal link between elevated systemic inflammation biomarkers and poor survival has been demonstrated in cancer patients. However, the evidence for this correlation in endometrial cancer (EC) is too weak ...

Growth of Acinetobacter baumannii in pellicle enhanced the expression of potential virulence factors 

Marti, Sara; Nait Chabane, Yassine; Alexandre, Stéphane; Coquet, Laurent; Vila Estapé, Jordi; Jouenne, Thierry; Dé, Emmanuelle (Fecha de publicación: 2018-10-01)

Background Interestingly, Acinetobacter baumannii presents an enhanced capacity to form biofilms (also named pellicles) at the air-liquid interface as compared to the other Acinetobacter species. This characteristic questions ...

A novel strategy based on genomics and specific PCR reveals how a multidrug resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence. 

Pérez-Lago, Laura; Izco, Santiago; Herranz, Marta; Tudó i Vilanova, Griselda; Carcelén, María; Comas, Iñaki; Sierra, Olalla; González Martín, Julián; Ruiz-Serrano, María J.; Eyene, Juan; Bouza, Emilio; García de Viedma, Darío (Fecha de publicación: 2018-10-10)

OBJECTIVE: Molecular epidemiology techniques in tuberculosis (TB) can identify high-risk strains that are actively transmitted. We aimed to implement a novel strategy to optimize the identification and control of ...

High within-host diversity found from direct genotyping on post-mortem tuberculosis specimens in a high-burden setting 

Rodríguez Grande, Cristina; Hurtado, Juan Carlos; Rodríguez Maus, Sandra; Casas, Isaac; Castillo, Paola; Navarro, Mireia; Rakislova, Natalia; García-Basteiro, Alberto L.; Carrilho, Carla; Fernandes, Fabiola; Lovane, Lucilia; Jordao, Dercio; Ismail, Mamudo Rafik; Lorenzoni, Cesaltina; Cossa, Anelsio; Mandomando, Inácio; Bassat Orellana, Quique; Menéndez, Clara; Ordi i Majà, Jaume; Muñoz, Patricia; Pérez Lago, Laura; García de Viedma, Darío; Martínez Yoldi, Miguel Julián (Fecha de publicación: 2022-05-09)

Objectives: To characterize the clonal complexity in Mycobacterium tuberculosis (MTB) infections considering factors that help maximize the detection of coexisting strains/variants. Methods: Genotypic analysis by Mycobacterial ...

Convulsión neonatal 

Pastor Durán, Xavier (Fecha de publicación: 2014-11-12)

Se define el 'estado convulsivo neonatal como una convulsión (cualquiera que sea su forma) que se mantiene de forma continuada o bien que tras desaparecer se repite en un período inferior a 20 minutos a pesar de un tratamiento ...

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics. 

Speedy, Helen E.; Beekman, Renée; Chapaprieta, Vicente; Orlando, Giulia; Law, Philip J.; Martín García, David; Gutiérrez-Abril, Jesús; Catovsky, Daniel; Beà Bobet, Sílvia M.; Clot Razquin, Guillem; Puiggròs, Montserrat; Torrents Arenales, David; Puente, Xose S.; Allan, James M.; López-Otin, Carlos; Campo Güerri, Elias; Houlston, Richard S.; Martín-Subero, José Ignacio (Fecha de publicación: 2020-01-16)

Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin accessibility, ...

Assessment of In Vitro Cefiderocol Susceptibility and Comparators against an Epidemiologically Diverse Collection of Acinetobacter baumannii Clinical Isolates. 

Delpierre, Clara Celia; Ramírez, Ángel; Muñoz, Laura; Longshaw, Christopher; Roca, Ignasi; Vila Estapé, Jordi (Fecha de publicación: 2022-05-19)

Cefiderocol is a catechol-substituted siderophore cephalosporin combining rapid penetration into the periplasmic space with increased stability against β-lactamases. This study provides additional data on the in vitro ...

Biological prognostic and therapeutic impact of the epigenome in CLL 

Maiques Diaz , Alba; Martín-Subero, José Ignacio (Fecha de publicación: 2024-11-18)

Chronic lymphocytic leukemia (CLL) is characterized by widespread alterations in the genetic and epigenetic landscapes which seem to underlie the variable clinical manifestations observed in patients. Over the last decade, ...

La dimensión temporal de la enfermedad crónica: duración, diagnóstico y edad 

Masana, Lina (Fecha de publicación: 2025-06-12)

Las enfermedades y malestares crónicos se experimentan cronológicamente y biográficamente, a lo largodel tiempo y de la vida de la persona. Por tratarse de problemas de salud de larga duración, presentanciertas particularidades ...

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas. 

Abate, Francesco; Silva-Almeida, Ana C. da; Zairis, Sakellarios; Robles Valero, Javier; Couronne, Lucile; Khiabanian, Hossein; Quinn, S. Aidan; Kim, Mi-Yeon; Laginestra, M.Antonella; Kim, Christine; Fiore, Danilo; Bhagat, Govind; Piris, Miguel A.; Campo Güerri, Elias; Lossos, Izidore S.; Bernard, Olivier A.; Inghirami, Giorgio; Pileri, Stefano Aldo; Bustelo, Xosé R.; Rabadán, Raul; Ferrando, Adolfo A.; Palomero, Teresa (Fecha de publicación: 2019-05-06)

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA ...

The impact of frailty on admission to home care services and nursing homes: Eight-year follow-up of a community-dwelling, older adult, Spanish cohort 

Cegri, Francisco; Orfila, Francesc; Abellana Sangrà, Rosa Mari; Pastor Valero, María (Fecha de publicación: 2021-05-11)

Background: Frailty in older adults is a common multidimensional clinical entity, a state of vulnerability to stressors that increases the risk of adverse outcomes such as functional decline, institutionalization or death. ...

Oncology: Management of Elderly Cancer Patients 

Arenas Prat, Meritxell; Nguyen, Nam; Franco, Pierfrancesco; Selek, Ugur; Rovirosa Casino, Angeles; Sabater, Sebastià (Fecha de publicación: 2020-04-24)

Timing the initiation of multiple myeloma. 

Rustad, Even H.; Yellapantula, Venkata; Leongamornlert, Daniel; Bolli, Niccolò; Ledergor, Guy; Nadeu Prat, Ferran; Angelopoulos, Nicos; Dawson, Kevin J.; Mitchell, Thomas J.; Osborne, Robert J.; Ziccheddu, Bachisio; Carniti, Cristiana; Montefusco, Vittorio; Corradini, Paolo; Anderson, Kenneth C.; Moreau, Philippe; Papaemmanuil, Elli; Alexandrov, Ludmil B.; Puente, Xose S.; Campo Güerri, Elias; Siebert, Reiner; Avet-Loiseau, Hervé; Landgren, Ola; Munshi, Nikhil; Campbell, Peter J.; Maura, Francesco (Fecha de publicación: 2021-07-06)

The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of mutational processes shaping multiple myeloma evolution in a large cohort ...

Psychiatric and psychological assessment of Spanish patients with drug-resistant epilepsy and psychogenic nonepileptic seizures (PNES) with no response to previous treatments 

Sobregrau Sangrà, Pau; Baillès, Eva; Carreño, Mar; Donaire Pedraza, Antonio Jesús; Boget Llucià, Teresa; Setoain Perego, Xavier; Bargalló Alabart, Núria; Rumià, Jordi; Sánchez-Vives, María Victoria; Pintor Pérez, Luis (Fecha de publicación: 2025-01-03)

Objective: Psychogenic nonepileptic seizures (PNES) are common imitators of epileptic seizures. Refractoriness to antiseizure medication hinders the differential diagnosis between ES and PNES, carrying deleterious consequences ...