Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 21-40 of 675
Synthesis of Tetra-ortho-Methoxylated Azobenzene Photoswitches via Sequential Catalytic C-H Activation and Methoxylation
Functionalized tetra-ortho-methoxyazobenzenes have been prepared in a two-step approach based on palladium-catalyzed C–H ortho bromination of azobenzenes, followed by copper-catalyzed methoxylation. The method has shown a ...
Molecular Surface Quantification of Multi-Functionalized Gold Nanoparticles Using UV-Vis Spectroscopy Deconvolution
Multifunctional gold nanoparticles (AuNPs) are of great interest, owing to their vast potential for use in many areas including sensing, imaging, delivery, and medicine. A key factor in determining the biological activity ...
Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death
<p>Quantum biological electron tunnelling (QBET) underpins cellular behaviour. Control of</p><p>electrical-molecular communication could revolutionise the development of disruptive</p><p>technologies for understanding and ...
Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT ...
Site selectivity in Pd-catalyzed reactions of α-diazo-α-(methoxycarbonyl)acetamides: effects of catalysts and substrate substitution in the synthesis of oxindoles and ß-lactams
The Pd-catalyzed intramolecular carbene C-H insertion of α-diazo-α-(methoxycarbonyl)acetamides to prepare oxindoles as well as β-lactams was studied. In order to identify what factors influence the selectivity of the ...
Developmental effects and genotoxicity of ten water disinfection by-products in zebrafish
Disinfection by-products are contaminants produced during drinking water disinfection. Several DBPs have been implicated in a variety of toxic effects, mainly carcinogenic and genotoxic effects. Moreover, DBPs exposure has ...
Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model
The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been demonstrated in several studies. UNC0642, a specific and potent inhibitor of methyltransferase activity G9a/GLP (G9a-like) complex, was evaluated ...
KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid
Bempedoic acid (BemA) is an ATP-citrate lyase (ACLY) inhibitor used to treat hypercholesterolemia. We studied the anti-steatotic effect of BemA, and the mechanisms involved, in a model of fatty liver in female rats obtained ...
Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP
Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the causes of PD are not understood, evidence ...
Resveratrol derivatives: Synthesis and their biological activities
Resveratrol, a natural compound known especially for its antioxidant properties and protective action, opens the door for both it and its structural derivatives to be considered not only as chemopreventive but also as ...
El consumo excesivo de fructosa en el embarazo puede dañar la placenta y provocar estrés oxidativo en los fetos
La fructosa se utiliza para fabricar el sirope de maíz rico en fructosa (HFCS, en sus siglas en inglés), el cual se usa para edulcorar gran variedad de alimentos (comidas procesadas, bollería y repostería industrial, ...
Modulation and Protection Effects of Antioxidant Compounds against Oxidant Induced Developmental Toxicity in Zebrafish
The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict in vivo protective activity or to determine their underlying mechanisms of action. The aim of this ...
Microwave-assisted benzylic C-H activation using ruthenium catalysts. Synthesis of ß-lactams
An expeditious synthesis of ß-lactams from benzyl-tethered trichloroacetamides using ruthenium catalysts in toluene under microwave activation was achieved. The new C(sp3)-C(sp3) bond formation takes place through a ...
The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds
t: The antioxidant activity of food compounds is one of the properties generating the most interest, due to its health benefits and correlation with the prevention of chronic disease. This activity is usually measured using ...
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal ...
Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
Adenosine (ARs) and metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are modulated in the brain of SAMP8 mice, an animal model of Alzheimer's disease (AD). In the present work, it is ...
¿La presencia de cannabis en saliva es suficiente para confirmar la conducción bajo sus efectos?
In Spain today, the presence of drugs in saliva is considered sufficient to confirm driving under its effects, although the concentration obtained is near the threshold limits of the analytic system. This legal approach ...
Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer's Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving ...
Water-Dispersible BODIPY Multifunctionalized Silicon Oxide Nanoparticles for Glutathione Sensing
Glutathione (GSH), a thiol containing small peptide, plays pivotal roles in maintaining cellular redox balance, metabolism, detoxification, and scavenging of free radicals. Aberrant GSH levels in cells and tissues are ...
A carboxylesterase, Esterase-6, modulates sensory physiological and behavioural response dynamics to pheromone in Drosophila
Background: Insects respond to the spatial and temporal dynamics of a pheromone plume, which implies not only a strong response to"odor on", but also to"odor off". This requires mechanisms geared toward a fast signal ...
