Bioquímica i Fisiologia: Recent submissions
Now showing items 21-40 of 634
Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMAdifferentiated THP-1 cells
Background: In the context of tumor immunology, tumor cells have been shown to overexpress CD47, an antiphagocytic signal directed to macrophages to escape from phagocytosis by interacting with Signal Regulatory Protein α ...
Evaluation of Anti-Tyrosinase and Antioxidant Properties of Four Fern Species for Potential Cosmetic Applications
Ferns are poorly explored species from a pharmaceutical perspective compared to other terrestrial plants. In this work, the antioxidant and tyrosinase inhibitory activities of hydrophilic and lipophilic extracts, together ...
Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells
Gut microbiota plays a critical role in maintaining human intestinal homeostasis and host health. Bacterial extracellular vesicles are key players in bacteria-host communication, as they allow delivery of effector molecules ...
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Background & aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes to ...
Rotavirus double infection model to study preventive dietary interventions
Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting ...
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation
Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused ...
Activation of immune and defense responses in the intestinal mucosa by outer membrane vesicles of commensal and probiotic Escherichia coli strains
The influence of microbiota in human health is well established. Imbalances in microbiome structure have been linked to several diseases. Modulation of microbiota composition through probiotic therapy is an attempt to ...
Exploring the Impact of Extra Virgin Olive Oil on Maternal Immune System and Breast Milk Composition in Rats
<span style="color:rgb( 34 , 34 , 34 )">Maternal breast milk plays a key role in providing newborns with passive immunity and stimulating the maturation of an infant’s immune system, protecting them from many diseases. It ...
5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters
5-hydroxytryptamine (5-HT) is derived from the essential amino acid L-tryptophan. Although the compound has been studied extensively for its neuronal handling and synaptic actions, serotonin 5-HT receptors can be found ...
Alteractions in the mucosal immune system by a chronic exhausting exercise in Wistar rats
Exhausting exercise can disturb immune and gastrointestinal functions. Nevertheless, the impact of it on mucosal-associated lymphoid tissue has not been studied in depth. Here, we aim to establish the effects of an intensive ...
Estudi del mecanisme de fagocitosi dels corpora amylacea del líquid cefalorraquidi humà
Los corpora amylacea son unos cuerpos granulares que se acumulan en el cerebro humano durante el envejecimiento...
Estudi de tècniques immunològiques a través de “Podcasts” elaborats pels estudiants
Projecte: 2013-PID-UB/10
Utilization of Glycerol for Endogenous Glucose and Glycogen Synthesis in Seabass (Dicentrarchus labrax): a Potential Mechanism for Sparing Amino Acid Catabolism in Carnivorous Fish
Glycerol is a well-tolerated additive in aquafeeds. We hypothesized that in seabass, a carnivorous fish whose endogenous carbohydrate demands are mostly met by hepatic amino acid gluconeogenesis, glycerol effectively ...
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore ...
Protective effect of guarana-loaded liposomes on hemolytic activity
Paullinia cupana var. sorbilis (Mart.) Ducke, popularly known as guarana, is one of the most promising plants in Brazilian flora and has attracted considerable interest from the scientific community owing to its numerous ...
Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise
Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin plummet early during adulthood in mice, ...
Hydroxy-Selenomethionine, an Organic Selenium Source, Increases Selenoprotein Expression and Positively Modulates the Inflammatory Response of LPS-Stimulated Macrophages
The role of 2-hydroxy-(4-methylseleno)butanoic acid (OH-SeMet), a form of organic selenium (Se), in selenoprotein synthesis and inflammatory response of THP1-derived macrophages stimulated with lipopolysaccharide (LPS) has ...
Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian Cells
In this study, we describe the correction of single-point mutations in mammalian cells by repair-polypurine reverse Hoogsteen hairpins (repair-PPRHs). These molecules consist of (1) a PPRH hairpin core that binds to a ...
Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among ...
Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth
Etiology of colorectal cancer (CRC) is related, at least in part, with nutritional profile and epidemiological data indicating a key role of dietary fat on CRC pathogenesis. Moreover, inflammation and eicosanoids produced ...
