Bioquímica i Fisiologia: Enviaments recents
Ara mostrant els elements 241-260 de 634
Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on ...
Comparació de dos métodes de detecció de l'activitat motora en petits rosegadors
L'estudi de l'activitat motora en animals d'experimentació ha estat objecte d'interès, especialment en els camps de psicofarmacologia i l'etologia. Cada cop les tècniques que es fan servir en aquest tipus d'estudis van ...
Targeting AgRP neurons to maintain energy balance: lessons from animal models
The current obesity epidemic is a major worldwide health and economic burden. In the modern environment, an increase in the intake of high-fat and high-sugar foods plays a crucial role in the development of obesity by ...
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters
Background: Circadian theories for major depressive disorder have suggested that the rhythm of the circadian pacemaker is misaligned. Stable phase relationships between internal rhythms, such as temperature and rest/activity, ...
Maslinic acid-enriched diet decreases intestinal tumorigenesis in ApcMin/+ mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancerrelated death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted ...
Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood-Brain Barrier
Receptor-mediated transcytosis has been widely studied as a possible strategy to transport neurotherapeutics across the blood-brain barrier (BBB). Monoclonal antibodies directed against the transferrin receptor (TfR) have ...
Mechanisms involved in down-regulation of intestinal IgA in rats by high cocoa intake
Previous studies have shown that rat intestinal immunoglobulin A (IgA) concentration and lymphocyte composition of the intestinal immune system were influenced by a highly enriched cocoa diet. The aim of this study was to ...
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases
The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme¿such as 4-(2-aminoethyl)benzenesulfonyl ...
Polypurine Reverse Hoogsteen Hairpins as a tool for gene repair and editing
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Persistence of Anti SARS-CoV-2 Antibodies in Breast Milk from Infected and Vaccinated Women after In Vitro-Simulated Gastrointestinal Digestion
Breastfeeding is key for infant development and growth. Breast milk contains different bioactive compounds including antibodies. Recent studies have demonstrated the presence of breast milk SARS-CoV-2 antibodies after ...
Modulation of Serotonin-Related Genes by Extracellular Vesicles of the Probiotic Escherichia coli Nissle 1917 in the Interleukin-1β-Induced Inflammation Model of Intestinal Epithelial Cells.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition involving dysregulated immune responses and imbalances in the gut microbiota in genetically susceptible individuals. Current therapies for IBD often have ...
Preventive Effect of a Postbiotic and Prebiotic Mixture in a Rat Model of Early Life Rotavirus Induced-Diarrhea
Rotavirus (RV) is the main cause of gastroenteritis in children. Prebiotics and, more recently, postbiotics are used for preventing and treating gastrointestinal infections. The aim of this study was to analyze the effects ...
The role of counterions in the membrane-disruptive properties of pH-sensitive lysine-based surfactants
Surfactants are among the most versatile and widely used excipients in pharmaceuticals. This versatility, together with their pH-responsive membrane-disruptive activity and low toxicity, could also enable their potential ...
Evaluation of non-extruded and extruded pecan (Carya illinoinensis) shell powder as functional ingredient in bread and wheat tortilla
Pecan shell is a source of dietary fiber and phytochemicals, both necessary in the human diet. Therefore, pecan shell powder could be used as a supplement in the preparation of food products. The present study evaluated ...
Influence of consumption of two Peruvian cocoa populations on mucosal and systemic immune response in an allergic asthma rat model
Different cocoa populations have demonstrated a protective role in a rat model of allergic asthma by attenuating the immunoglobulin (Ig) E synthesis and partially protecting against anaphylactic response. The aim of this ...
Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing ...
Aggregation Behavior, Antibacterial Activity and Biocompatibility of Catanionic Assemblies Based on Amino Acid-Derived Surfactants
Abstract: The surface activity, aggregates morphology, size and charge characteristics of binary catanionic mixtures containing a cationic amino acid-derived surfactant N(π), N(τ)-bis(methyl)- L-Histidine tetradecyl amide ...
Regulation of N-Myc downstream regulated gene 2 by bile acids
Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma ...
Gene Correction of Point Mutations Using PolyPurine Reverse Hoogsteen Hairpins Technology
Monogenic disorders are often the result of single point mutations in specific genes,leading to the production of non-functional proteins. Different blood disorders suchas ß-thalassemia, sickle cell disease, hereditary ...
