Screening Anti-Inflammatory Effects of Flavanones Solutions 

Bustos Salgado, Paola; Carrera Andrade, Berenice; Domínguez Villegas, Valeri; Díaz Garrido, Natalia; Rodríguez Lagunas, María José; Baldomà Llavinés, Laura; Mallandrich Miret, Mireia; Calpena Campmany, Ana Cristina; Garduño Ramírez, María Luisa del Carmen (Fecha de publicación: 2021-11-04)

There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and ...

A new Food Frequency Questionnaire to assess chocolate and cocoa consumption 

Vicente, Filipa; Saldaña-Ruíz, Sandra; Rabanal i Tornero, Manel; Rodríguez Lagunas, María José; Pereira, Paula; Pérez-Cano, Francisco J.; Castell, Margarida (Fecha de publicación: 2019-02-05)

Objective Cocoa has been highlighted as a food with potential benefits to human health because of its polyphenol content. However, few studies show the contribution of cocoa and chocolate products in polyphenol intake. The ...

The Breast Milk Immunoglobulinome 

Rio-Aige, Karla; Azagra Boronat, Ignasi; Castell, Margarida; Selma-Royo, Marta; Collado, Maria Carmen; Rodríguez Lagunas, María José; Pérez-Cano, Francisco J. (Fecha de publicación: 2021-06-17)

Breast milk components contribute to the infant's immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; ...

Effect of cocoa's theobromine on intestinal microbiota of rats 

Martín-Peláez, Sandra; Camps i Bossacoma, Mariona; Massot Cladera, Malen; Rigo Adrover, Maria del Mar; Franch i Masferrer, Àngels; Pérez-Cano, Francisco J.; Castell, Margarida (Fecha de publicación: 2020-06-15)

SCOPE: To establish the role of cocoa theobromine on gut microbiota composition and fermentation products after cocoa consumption in rats. METHODS AND RESULTS: Lewis rats were fed either a standard diet (RF diet), a diet ...

Pseudomonas germanica sp. nov., isolated from Iris germanica rhizomes 

Atanasov, Kostadin Evgeniev; Miñana i Galbis, David; Gallego, Julia; Serpico, Annabel; Bosch, Montserrat; Altabella Artigas, Teresa; Ferrer i Prats, Albert (Fecha de publicación: 2022-03-31)

Through bacterial plant-endophyte extraction from rhizomes of Iris germanica plant, a Gram-stain-negative, aerobic, catalase- and oxidase-positive gammaproteobacterial strain, referred to as FIT28T, was isolated. FIT28T ...

Phenolic Profile, EPR Determination, and Antiproliferative Activity against Human Cancer Cell Lines of Anthyllis vulneraria Extracts 

Ouerfelli, Manel; Metón Teijeiro, Isidoro; Codina-Torrella, Idoia; Almajano Pablos, Ma. Pilar (María Pilar) (Fecha de publicación: 2023-02-24)

In the current work, the leaf and flower extracts of Anthyllis vulneraria were evaluated for their chemical characterization using HPLC-MS and for their radical scavenging capacity toward methoxy radicals produced by a ...

Cytotoxic evaluation of (2S)-5,7-dihydroxy-6-prenylflavanone derivatives loaded PLGA nanoparticles against MiaPaCa-2 cells 

Andrade Carrera, Berenice; Clares Naveros, Beatriz; Noé Mata, Verónica; Mallandrich Miret, Mireia; Calpena Campmany, Ana Cristina; Garduño Ramírez, María Luisa del Carmen (Fecha de publicación: 2018-05-14)

The search for new alternatives for the prevention and treatment of cancer is extremely important to minimize human mortality. Natural products are an alternative to chemical drugs, since they are a source of many potential ...

Potential of antioxidant extracts produced by aqueous processing ofrenewable resources for the formulation of cosmetics 

Balboa, Elena M.; Soto, Maria Luisa; Nogueira, Daniele R.; González-López, Noelia; Conde, Enma; Moure, Andrés; Vinardell Martínez-Hidalgo, Ma. Pilar; Mitjans Arnal, Montserrat; Domínguez, Herminia (Fecha de publicación: 2014-07-16)

The performance of natural extracts obtained from underutilized and residual vegetal and macroalgal biomass processed with food-grade green solvents was compared with that of commercial antioxidants. Selected extracts were ...

Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice 

Pozo, Macarena; Rodríguez-Rodríguez, Rosalía; Ramírez, Sara; Seoane-Collazo, Patricia; López, Miguel; Serra i Cucurull, Dolors; Herrero Rodríguez, Laura; Casals i Farré, Núria (Fecha de publicación: 2020-07-07)

Carnitine palmitoyltransferase (CPT) 1C, a brain-specific protein localized in the endoplasmic reticulum of neurons, is expressed in almost all brain regions. Based on global knockout (KO) models, CPT1C has demonstrated ...

Dopamine in health and disease: much more than a neurotransmitter 

Franco Fernández, Rafael; Reyes Resina, Irene; Navarro Brugal, Gemma (Fecha de publicación: 2021-04-20)

Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of ...

Monocarboxylate transporter 1 mediates DL-2-hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers. 

Rodríguez Lagunas, María José; Martín Venegas, Raquel; Ferrer i Roig, Ruth (Fecha de publicación: 2024-02-14)

<p>The methionine hydroxy analogue DL-2-hydroxy-(4-methylthio)butanoic acid (DL-HMB) is a supplementary source of methionine commonly</p><p>added to commercial animal diets to satisfy the total sulfur amino acid requirement. ...

Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs 

González Solé, Francesc; Criado Mesas, Lourdes; Villodre, Carmen; García, Wellington C.; Farré, Mercè; Borda, Elisabet; Pérez-Cano, Francisco J.; Folch, Josep M.; Solà Oriol, David; Pérez, José F. (Fecha de publicación: 2021-04-15)

This study was conducted to investigate the effects of dietary supplementation of porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination of both, on growth performance and the expression of genes ...

Trencament de la funció epitelial de barrera en la salmonel·losi (Seminaris de Recerca 2013) 

Martín Venegas, Raquel (Fecha de publicación: 2016-04-18)

Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line 

Ramiro Puig, Emma; Franch i Masferrer, Àngels; Castellote i Bargalló, M. Cristina; Andrés Lacueva, Ma. Cristina; Izquierdo Pulido, Maria; Castell, Margarida (Fecha de publicación: 2015-12-22)

We analysed the effect of (-)-epicatechin and cocoa extract on the activation of a lymphoid cell line. Particularly the expression of IL-2 receptor alpha (IL-2Ralpha or CD25) and, the secretion of IL-2 and IL-4 were ...

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity 

Rodríguez-Rodríguez, Rosalía; Miralpeix, Cristina; Fosch, Anna; Pozo, Macarena; Calderón Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López, Miguel; Herrero Rodríguez, Laura; Serra i Cucurull, Dolors; Casals i Farré, Núria (Fecha de publicación: 2019-02-05)

OBJECTIVE: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus (VMH) is involved in ...

Antioxidants versus Food Antioxidant Additives and Food Preservatives 

Franco Fernández, Rafael; Navarro Brugal, Gemma; Martínez-Pinilla, Eva (Fecha de publicación: 2021-02-11)

Natural and processed foods are fragile and can become unpalatable and/or rotten. The processed food industry uses preservatives to enable distribution, even to different continents, and to extend the useful life of their ...

Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota 

Azagra Boronat, Ignasi; Tres Oliver, Alba; Massot Cladera, Malen; Franch i Masferrer, Àngels; Castell, Margarida; Guardiola Ibarz, Francesc; Pérez-Cano, Francisco J.; Rodríguez Lagunas, María José (Fecha de publicación: 2020-05-14)

Probiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of Lactobacillus fermentum CECT5716 during pregnancy and lactation periods impacts maternal and offspring ...

Mediterranean Diet, Microbiota and Immunity 

Pérez-Cano, Francisco J. (Fecha de publicación: 2023-02-23)

It is well established that the diet, among other external influencing factors, also known as the exposome, has a key role in the prevention and management of different diseases. The health benefits of dietary patterns are ...

Alterations in the innate immune system due to exhausting exercise in intensively trained rats 

Estruel Amades, Seila; Camps i Bossacoma, Mariona; Massot Cladera, Malen; Pérez-Cano, Francisco J.; Castell, Margarida (Fecha de publicación: 2020-05-29)

It is known that intensive physical activity alters the immune system's functionality. However, the influence of the intensity and duration of exercise needs to be studied in more depth. We aimed to establish the changes ...

G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease 

Du, Hai-Ning; Bellver Sanchis, Aina; Geng, Qizhi; Navarro Brugal, Gemma; Ávila-López, Pedro A.; Companys Alemany, Júlia; Marsal García, Laura; Larramona-Arcas, Raquel; Miró Martí, Ma. Lluïsa; Pérez Bosque, Anna; Ortuño Sahagún, Daniel; Banerjee, Deb Ranjan; Choudhary, Bhanwar Singh; Soriano Zaragoza, Francesc X. (Francesc Xavier); Poulard, Coralie; Pallàs i Llibería, Mercè, 1964-; Griñán Ferré, Christian (Fecha de publicación: 2024-04-30)

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we show the upregulation of G9a and H3K9me2 in the brains of AD patients. Interestingly, treatment with a G9a inhibitor ...